GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (2024)

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (1) https://doi.org/10.1038/s41586-023-06034-3 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (2)

Видання: Nature, 2023, №7962, с.764-768

Видавець: Springer Science and Business Media LLC

Автори:

  1. Erola Pairo-Castineira
  2. Konrad Rawlik
  3. Andrew D. Bretherick
  4. Ting Qi
  5. Yang Wu
  6. Isar Nassiri
  7. Glenn A. McConkey
  8. Marie Zechner
  9. Lucija Klaric
  10. Fiona Griffiths
  11. Wilna Oosthuyzen
  12. Athanasios Kousathanas
  13. Anne Richmond
  14. Jonathan Millar
  15. Clark D. Russell
  16. Tomas Malinauskas
  17. Ryan Thwaites
  18. Kirstie Morrice
  19. Sean Keating
  20. David Maslove
  21. Alistair Nichol
  22. Malcolm G. Semple
  23. Julian Knight
  24. Manu Shankar-Hari
  25. Charlotte Summers
  26. Charles Hinds
  27. Peter Horby
  28. Lowell Ling
  29. Danny McAuley
  30. Hugh Montgomery
  31. Peter J. M. Openshaw
  32. Colin Begg
  33. Timothy Walsh
  34. Albert Tenesa
  35. Carlos Flores
  36. José A. Riancho
  37. Augusto Rojas-Martinez
  38. Pablo Lapunzina
  39. Sara Clohisey
  40. Johnny Millar
  41. Manu Shankar-Hari
  42. Emma Aitkin
  43. Latha Aravindan
  44. Ruth Armstrong
  45. J. Kenneth Baillie
  46. Heather Biggs
  47. Ceilia Boz
  48. Adam Brown
  49. Primmy Chikowore
  50. Richard Clark
  51. Audrey Coutts
  52. Judy Coyle
  53. Louise Cullum
  54. Sukamal Das
  55. Nicky Day
  56. Lorna Donnelly
  57. Esther Duncan
  58. Paul Finernan
  59. Max Head Fourman
  60. Anita Furlong
  61. James Furniss
  62. Bernadette Gallagher
  63. Tammy Gilchrist
  64. Ailsa Golightly
  65. Fiona Griffiths
  66. Katarzyna Hafezi
  67. Debbie Hamilton
  68. Ross Hendry
  69. Naomi Kearns
  70. Dawn Law
  71. Rachel Law
  72. Sarah Law
  73. Rebecca Lidstone-Scott
  74. Christen Lauder
  75. Louise Macgillivray
  76. Alan Maclean
  77. Hanning Mal
  78. Sarah McCafferty
  79. Ellie McMaster
  80. Jen Meikle
  81. Shona C. Moore
  82. Sheena Murphy
  83. Hellen Mybaya
  84. Miranda Odam
  85. Wilna Oosthuyzen
  86. Chenqing Zheng
  87. Jiantao Chen
  88. Nick Parkinson
  89. Trevor Paterson
  90. Petra Tucker
  91. Katherine Schon
  92. Andrew Stenhouse
  93. Mihaela Das
  94. Maaike Swets
  95. Helen Szoor-McElhinney
  96. Filip Taneski
  97. Lance Turtle
  98. Tony Wackett
  99. Mairi Ward
  100. Jane Weaver
  101. Nicola Wrobel
  102. Marie Zechner
  103. Jacqueline Pan
  104. Neus Grau
  105. Tim Owen Jones
  106. Rosario Lim
  107. Martina Marotti
  108. Christopher Whitton
  109. Aneta Bociek
  110. Sara Campos
  111. Gill Arbane
  112. Manu Shankar-Hari
  113. Marlies Ostermann
  114. Mina Cha
  115. Fabiola DAmato
  116. Eirini Kosifidou
  117. Shelley Lorah
  118. Kyma Morera
  119. Sarah Bircham
  120. Laura Brady
  121. Keith Hugill
  122. Jeremy Henning
  123. Stephen Bonner
  124. Evie Headlam
  125. Jessica Jones
  126. Abigail List
  127. Joanne Morley
  128. Amy Welford
  129. Bobette Kamangu
  130. Anitha Ratnakumar
  131. Abiola Shoremekun
  132. Zoe Alldis
  133. Raine Astin-Chamberlain
  134. Fatima Bibi
  135. Jack Biddle
  136. Sarah Blow
  137. Matthew Bolton
  138. Catherine Borra
  139. Ruth Bowles
  140. Maudrian Burton
  141. Yasmin Choudhury
  142. Amber Cox
  143. Amy Easthope
  144. Patrizia Ebano
  145. Stavros Fotiadis
  146. Jana Gurasashvili
  147. Rosslyn Halls
  148. Pippa Hartridge
  149. Delordson Kallon
  150. Jamila Kassam
  151. Ivone Lancoma-Malcolm
  152. Maninderpal Matharu
  153. Peter May
  154. Oliver Mitchelmore
  155. Tabitha Newman
  156. Mital Patel
  157. Jane Pheby
  158. Irene Pinzuti
  159. Zoe Prime
  160. Oleksandra Prysyazhna
  161. Julian Shiel
  162. Melanie Taylor
  163. Carey Tierney
  164. Olivier Zongo
  165. Suzanne Wood
  166. Anne Zak
  167. David Collier
  168. Manuela Mundy
  169. Christopher Thompson
  170. Lisa Pritchard
  171. Minnie Gellamucho
  172. David Cartlidge
  173. Nageswar Bandla
  174. Lucy Bailey
  175. Michelle Davies
  176. Jane Delaney
  177. Leanne Scott
  178. Marwa Abdelrazik
  179. Frater Alasdair
  180. David Carter
  181. Munzir Elhassan
  182. Arunkumar Ganesan
  183. Samuel Jenkins
  184. Zoe Lamond
  185. Dharam Purohit
  186. Kumar Rohit
  187. Malik Saleem
  188. Alanna Wall
  189. Kugan Xavier
  190. Dhanalaksmi Bakthavatsalam
  191. Kirolos Gehad
  192. Pakeerathan Gnanapragasam
  193. Kapil Jain
  194. Swati Jain
  195. Abdul Malik
  196. Naveen Pappachan
  197. Jeronimo Moreno-Cuesta
  198. Anne Haldeos
  199. Rachel Vincent
  200. Maryjane Oziegb
  201. Anna Cavazza
  202. Maeve co*ckrell
  203. Eleanor Corcoran
  204. Maria Depante
  205. Clare Finney
  206. Ellen Jerome
  207. Abigail Knighton
  208. Monalisa Nayak
  209. Evita Pappa
  210. Rohit Saha
  211. Sian Saha
  212. Andrew Dodd
  213. Kevin O’Reilly
  214. Mark McPhail
  215. Emma Clarey
  216. Harriet Noble
  217. John Smith
  218. Phoebe Coghlan
  219. Stephen Brett
  220. Anthony Gordon
  221. Maie Templeton
  222. David Antcliffe
  223. Dorota Banach
  224. Sarah Darnell
  225. Ziortza Fernandez
  226. Eleanor Jepson
  227. Amal Mohammed
  228. Roceld Rojo
  229. Sonia Sousa Arias
  230. Anita Tamang Gurung
  231. Jenny Wong
  232. Jaime Fernandez-Roman
  233. David O. Hamilton
  234. Emily Johnson
  235. Brian Johnston
  236. Maria Lopez Martinez
  237. Suleman Mulla
  238. Alicia A. C. Waite
  239. Karen Williams
  240. Victoria Waugh
  241. Ingeborg Welters
  242. Jessica Emblem
  243. Maria Norris
  244. David Shaw
  245. Archana Bashyal
  246. Sally Beer
  247. Paula Hutton
  248. Stuart McKechnie
  249. Neil Davidson
  250. Soya Mathew
  251. Grace Readion
  252. Jung Ryu
  253. Jean Wilson
  254. Shruti Agrawal
  255. Kay Elston
  256. Megan Jones
  257. Eoghan Meaney
  258. Petra Polgarova
  259. Muhammad Elbehery
  260. Charlotte Summers
  261. Esther Daubney
  262. Anthony Ng
  263. Jocelyn Marshall
  264. Nazima Pathan
  265. Katerina Stroud
  266. Deborah White
  267. Angela Andrew
  268. Saima Ashraf
  269. Amy Clark
  270. Martin Dent
  271. Margaret Langley
  272. Cecilia Peters
  273. Lucy Ryan
  274. Julia Sampson
  275. Shuying Wei
  276. Alice Baddeley
  277. Megan Meredith
  278. Lucy Morris
  279. Alexandra Gibbons
  280. Lisa McLoughlin
  281. Carlos Castro Delgado
  282. Victoria Clark
  283. Deborah Dawson
  284. Lijun Ding
  285. Georgia Durrant
  286. Obiageri Ezeobu
  287. Abiola Harrison
  288. William James Hurt
  289. Rebecca Kanu
  290. Ashley Kinch
  291. Susannah Leaver
  292. Ana Lisboa
  293. Jisha Mathew
  294. Kamal Patel
  295. Romina Pepermans Saluzzio
  296. John Rawlins
  297. Tinashe Samakomva
  298. Nirav Shah
  299. Christine Sicat
  300. Joana Texeira
  301. Joana Gomes De Queiroz
  302. Edna Fernandes Da Gloria
  303. Elena Maccacari
  304. Nikki Yun
  305. Soumendu Manna
  306. Sarah Farnell-Ward
  307. Maria Maizcordoba
  308. Maria Thanasi
  309. Hawakin Haji Ali
  310. Janice Hastings
  311. Lina Grauslyte
  312. Musarat Hussain
  313. Bobby Ruge
  314. Sam King
  315. Tatiana Pogreban
  316. Lace Rosaroso
  317. Helen Smith
  318. Mandeep-Kaur Phull
  319. Nikkita Adams
  320. George Franke
  321. Aparna George
  322. Erika Salciute
  323. Joanna Wong
  324. Karen Dunne
  325. Luke Flower
  326. Emma Sharland
  327. Sukhmani Sra
  328. Gillian Andrew
  329. Marie Callaghan
  330. Lucy Barclay
  331. Lucy Marshall
  332. Kenneth Baillie
  333. Maria Amamio
  334. Sophie Birch
  335. Kate Briton
  336. Sarah Clark
  337. Katerine Doverman
  338. Dave Hope
  339. Corrienne Mcculloch
  340. Scott Simpson
  341. Jo Singleton
  342. Rita Fernandez
  343. Meryem Allen
  344. David Baptista
  345. Rebecca Crowe
  346. Jonathan Fox
  347. Jacyntha Khera
  348. Adam Loveridge
  349. India McKenley
  350. Eriko Morino
  351. Andres Naranjo
  352. Denise O’Connor
  353. Richard Simms
  354. Kathryn Sollesta
  355. Andrew Swain
  356. Harish Venkatesh
  357. Rosie Herdman-Grant
  358. Anna Joseph
  359. Angela Nown
  360. Steve Rose
  361. David Pogson
  362. Helen Boxall
  363. Lutece Brimfield
  364. Helen Claridge
  365. Zoe Daly
  366. Shenu George
  367. Andrew Gribbin
  368. Yusuf Cheema
  369. Sean Cutler
  370. Owen Richards
  371. Anna Roynon-Reed
  372. Shiney Cherian
  373. Anne Emma Heron
  374. Gemma Williams
  375. Tamas Szakmany
  376. Abby Waters
  377. Kim Collins
  378. Jill Dunhill
  379. Ffion Jones
  380. Rebecca Morris
  381. Lucy Ship
  382. Amy Cardwell
  383. Syamlan Ali
  384. Ravi Bhatterjee
  385. Rachel Bolton
  386. Srikanth Chukkambotla
  387. Dabheoc Coleman
  388. Jack Dalziel
  389. Joseph Dykes
  390. Christopher Fine
  391. Bethan Gay
  392. Wendy Goddard
  393. Drew Goodchild
  394. Rhiannan Harling
  395. Muhammad Hijazi
  396. Sarah Keith
  397. Meherunnisa Khan
  398. Roseanna Matt
  399. Janet Ryan-Smith
  400. Samuel Saad
  401. Philippa Springle
  402. Jacqueline Thomas
  403. Nick Truman
  404. Aayesha Kazi
  405. Matthew Smith
  406. Heather Collier
  407. Chloe Davison
  408. Stephen Duberley
  409. Jeanette Hargreaves
  410. Janice Hartley
  411. Tahera Patel
  412. Ellen Smith
  413. Alissa Kent
  414. Emma Goodwin
  415. Ahmed Zaki
  416. Clare Tibke
  417. Susan Hopkins
  418. Hywel Gerrard
  419. Matthew Jackson
  420. Sara Bennett
  421. Liane Marsh
  422. Rebecca Mills
  423. Jessica Bell
  424. Helen Campbell
  425. Angela Dawson
  426. Steve Dodds
  427. Stacey Duffy
  428. Lisa Gallagher
  429. Gemma McCafferty
  430. Stacey Short
  431. Tracy Smith
  432. Kirsty Thomas
  433. Claire Walker
  434. Jessica Reynolds
  435. Bryan Yates
  436. Hayley McKie
  437. Maria Panteli
  438. Maria Thompson
  439. Gail Waddell
  440. Sarah De Beger
  441. Azmerelda Abraheem
  442. Charlie Dunmore
  443. Rumanah Girach
  444. Rhianna Jones
  445. Emily London
  446. Imrun Nagra
  447. Farah Nasir
  448. Hannah Sainsbury
  449. Clare Smedley
  450. Stephen Brearey
  451. Caroline Burchett
  452. Kathryn Cawley
  453. Maria Faulkner
  454. Helen Jeffrey
  455. Peter Bamford
  456. Firdaus Shaikh
  457. Lauren Slack
  458. Angela Davies
  459. Hollie Brooke
  460. Jose Cebrian Suarez
  461. Ruth Charlesworth
  462. Karen Hansson
  463. John Norris
  464. Alice Poole
  465. Rajdeep Sandhu
  466. Elizabeth Smithson
  467. Muthu Thirumaran
  468. Veronica Wagstaff
  469. Sarah Buckley
  470. Brendan Sloan
  471. Alastair Rose
  472. Amy Major
  473. Alexandra Metcalfe
  474. Christine Almaden-Boyle
  475. Pauline Austin
  476. Susan Chapman
  477. Alexandre Eros
  478. Louise Cabrelli
  479. Stephen Cole
  480. Clare Whyte
  481. Matt Casey
  482. Vasileios Bafitis
  483. George Tsinaslanidis
  484. Cassandra George
  485. Reena Khade
  486. Christopher Black
  487. Sundar Raj Ashok
  488. Sean Farley
  489. Elaine Brinkworth
  490. Rachel Harford
  491. Carl Murphy
  492. Marie Williams
  493. Luke Newey
  494. Hannah Toghill
  495. Sophie Lewis
  496. Tabitha Rees
  497. Ceri Battle
  498. Mark Baker
  499. Jenny Travers
  500. Karen Chesters
  501. Nicola Baxter
  502. Andrew Arnott
  503. Gordan McCreath
  504. Christopher McParland
  505. Laura Rooney
  506. Malcolm Sim
  507. Steven Henderson
  508. Lynn Abel
  509. Carol Dalton
  510. Sophie Kennedy-Hay
  511. Lynn O’Donohoe
  512. Megan O’Hare
  513. Izabela Orlikowska
  514. Natasha Parker
  515. Fiona McNeela
  516. Amanda Lyle
  517. Alistair Hughes
  518. Jayachandran Radhakrishnan
  519. Sian Gibson
  520. Hollie Bancroft
  521. Mary Bellamy
  522. Jacqueline Daglish
  523. Salma Kadiri
  524. Faye Moore
  525. Joanne Rhodes
  526. Mirriam Sangombe
  527. Zhane Peterkin
  528. James Scriven
  529. Margaret Carmody
  530. Juliet Cottle
  531. Emily Peasgood
  532. Laura Ortiz-Ruiz de Gordoa
  533. Claire Phillips
  534. Denise Skinner
  535. Zoe Cinquina
  536. Kate Howard
  537. Rosie Joy
  538. Samantha Roche
  539. Isobel Birkinshaw
  540. Joseph Carter
  541. Jo Ingham
  542. Nicola Marshall
  543. Harriet Pearson
  544. Zoe Scott
  545. Jo Dasgin
  546. Jaspret Gill
  547. Annette Nilsson
  548. Amy Bamford
  549. Diana Hull
  550. James Scriven
  551. Nafeesah Ahmadhaider
  552. Michelle Bates
  553. Christopher McGhee
  554. Hannah Ellis
  555. Gwenllian Sera Howe
  556. Jayaprakash Singh
  557. Natalie Stroud
  558. Lisa Roche
  559. Ceri Lynch
  560. Bethan Deacon
  561. Carla Pothecary
  562. Justyna Smeaton
  563. Kevin Agravante
  564. Vinodh Krishnamurthy
  565. Cynthia Diaba
  566. Lincy John
  567. Lai Lim
  568. Rajeev Jha
  569. Jasmine Egan
  570. Timothy Felton
  571. Susannah Glasgow
  572. Grace Padden
  573. Ozerah Choudhr
  574. Joanne Bradley-Potts
  575. Stuart Moss
  576. Saejohn Lingeswaran
  577. Peter Alexander
  578. Craig Brandwood
  579. Sofia Fiouni
  580. Luke Ward
  581. Schvearn Allen
  582. Jane Shaw
  583. Christopher Smith
  584. Oluronke Adanini
  585. Rebecca Collins
  586. Maines Msiska
  587. Linda Ofori
  588. Nikhil Bhatia
  589. Hayley Dolan
  590. Mark Brunton
  591. Jess Caterson
  592. Holly Coles
  593. Liza Keating
  594. Emma Tilney
  595. Nicola Jacques
  596. Matthew Frise
  597. Jennifer Armistead
  598. Shauna Bartley
  599. Parminder Bhuie
  600. Sabi Rai
  601. Gabriela Tomkova
  602. Sandra Greer
  603. Karen Shuker
  604. Ascanio Tridente
  605. Emma Dobson
  606. Jodie Hunt
  607. Redmond Tully
  608. Joy Dearden
  609. Andrew Drummond
  610. Prakash Kamath
  611. Emily Bullock
  612. Michelle Mulcahy
  613. Shelia Munt
  614. Grainne O’Connor
  615. Jennifer Philbin
  616. Chloe Rishton
  617. Chloe Scott
  618. Sarah Winnard
  619. Nurkamalia Hasni
  620. Rachel Gascoyne
  621. Joanne Hawes
  622. Kelly Pritchard
  623. Lesley Stevenson
  624. Amanda Whileman
  625. Sarah Beavis
  626. Lauren Bishop
  627. Cindy Cart
  628. Katie Dale
  629. Mary Kelly-Baxter
  630. Adam Mendelski
  631. Emma Moakes
  632. Rheanna Smith
  633. Jan Woodward
  634. Stephanie Wright
  635. Angela Allan
  636. Adriana Botello
  637. Jade Liew
  638. Jasmine Medhora
  639. Erin Trumper
  640. Felicity Savage
  641. Teresa Scott
  642. Marc Place
  643. Callum Kaye
  644. Sarah Benyon
  645. Suzie Marriott
  646. Linda Park
  647. Helen Quinn
  648. Daisy Skyes
  649. Lily Zitter
  650. Kizzy Baines
  651. Elizabeth Gordon
  652. Samantha Keenan
  653. Andrew Pitt
  654. Katharine Duffy
  655. Jane Ireland
  656. Gary Semple
  657. Lynne Turner
  658. Susanne Cathcart
  659. Dominic Rimmer
  660. Alex Puxty
  661. Kathryn Puxty
  662. Andrew Hurst
  663. Jennifer Miller
  664. Susan Speirs
  665. Lauren Walker
  666. Zena Bradshaw
  667. Joanna Brown
  668. Sarah Melling
  669. Stephen Preston
  670. Nicola Slawson
  671. Scott Warden
  672. Alanna Beasley
  673. Emma Stoddard
  674. Leonie Benham
  675. Jason Cupitt
  676. Melanie Caswell
  677. Lisa Elawamy
  678. Ashleigh Wignall
  679. Belinda Roberts
  680. Hannah Golding
  681. Samantha Leggett
  682. Michelle Male
  683. Martyna Marani
  684. Kirsty Prager
  685. Toran Williams
  686. Kim Golder
  687. Oliver Jones
  688. Rebecca Cusack
  689. Clare Bolger
  690. Rachel Burnish
  691. Michael Carter
  692. Susan Jackson
  693. Karen Salmon
  694. Jonathan Biss
  695. Maia Aquino
  696. Maria Croft
  697. Victoria Frost
  698. Ian White
  699. Keshnie Govender
  700. Natasha Webb
  701. Liana Stapleton
  702. Colin Wells
  703. Nikitas Nikitas
  704. Ana Sanchez-Rodriguez
  705. Kayleigh Spencer
  706. Bethan Stowe
  707. Yvonne Izzard
  708. Michelle Poole
  709. Sonja Monnery
  710. Sallyanne Trotman
  711. Valerie Beech
  712. Edward Combes
  713. Teishel Joefield
  714. Patrick Covernton
  715. Sarah Savage
  716. Elizabeth Woodward
  717. Julie Camsooksai
  718. Henrik Reschreiter
  719. Charlotte Barclay
  720. Yasmin DeAth
  721. Judith Dube
  722. Charlotte Humphrey
  723. Sarah Jenkins
  724. Emma Langridge
  725. Rebecca Milne
  726. Beverley Wadams
  727. Megan Woolco*ck
  728. Michael Brett
  729. Brian Digby
  730. Lisa Gemmell
  731. James Hornsby
  732. Patrick MacGoey
  733. Pauline O’Neil
  734. Richard Price
  735. Radha Sundaram
  736. Lynn Abel
  737. Natalie Rodden
  738. Nicola Thomson
  739. Kevin Rooney
  740. Susan Currie
  741. Natasha Parker
  742. Lauren Walker
  743. Philip Henderson
  744. Bethan Ogg
  745. Simon Whiteley
  746. Liz Wilby
  747. Kate Long
  748. Shailamma Matthew
  749. Sheila Salada
  750. Susan Trott
  751. Sarah Watts
  752. Zoe Friar
  753. Abigail Speight
  754. Victoria Bastion
  755. Humza Chandna
  756. Brice Djeugam
  757. Muhammad Haseeb
  758. Harriet Kent
  759. Gamu Lubimbi
  760. Sophie Murdoch
  761. Alastair Thomas
  762. Beena David
  763. Rachel Lorusso
  764. Ana Vochin
  765. Melchizedek Penacerrada
  766. Retno Wulandari
  767. Charlotte Heath
  768. Srinivas Jakkula
  769. Anna Morris
  770. Ashar Ahmed
  771. Arvind Nune
  772. Claire Buttriss
  773. Emma Whitaker
  774. Miriam Davey
  775. David Golden
  776. Amy Acklery
  777. Fabio Fernandes
  778. Bec Seaman
  779. Victoria Earl
  780. Amy Collins
  781. Waqas Khaliq
  782. Rachel Adam
  783. Estefania Treus
  784. Sarah Holland
  785. Jordan Alfonso
  786. Bethan Blackledge
  787. Michelle Bruce
  788. Laura Jayne Durrans
  789. Ayaa Eltayeb
  790. Jade Harris
  791. Samuel Hey
  792. Martin Hruska
  793. Thomas Lamb
  794. Joanne Rothwell
  795. Adele Fitzgerald
  796. Gabriella Lindergard
  797. Helen T-Michael
  798. Tracey Duncan
  799. Sharon Baxter-Dore
  800. Lisa Cooper
  801. Claire Fox
  802. Jacinta Guerin
  803. Tracey Hodgkiss
  804. Karen Connolly
  805. Paul McAlinden
  806. Victoria Bridgett
  807. Maggie Fearby
  808. A. Gulati
  809. Helen Hanson
  810. Sinead Kelly
  811. Louise McCormack
  812. Rachel Nixon
  813. Philip Robinson
  814. Victoria Slater
  815. Elaine Stephenson
  816. Andrea Webster
  817. K. Webster
  818. Carole Hays
  819. Anne Hudson
  820. Bijal Patel
  821. Ian Clement
  822. John Davis
  823. Sarah Francis
  824. Douglas Jerry
  825. Caroline Abernathy
  826. Louise Foster
  827. Andrew Gratrix
  828. Llucia Cabral-Ortega
  829. Matthew Hines
  830. Victoria Martinson
  831. Elizabeth Stones
  832. Karen Winter
  833. Esther Barrow
  834. Katharine Wylie
  835. Deborah Baines
  836. Katie Birchall
  837. Laurel Kolakaluri
  838. Richard Clark
  839. Anila Sukumaran
  840. Craig Brandwood
  841. Melanie Barker
  842. Deborah Paripoorani
  843. Lara Smith
  844. Charlotte Taylor
  845. Charlotte Downes
  846. Melanie Hayman
  847. Katie Riches
  848. Priya Daniel
  849. Deepak Subramanian
  850. Kathleen Holding
  851. Mary Hilton
  852. Carly McDonald
  853. Georgina Richardson
  854. Georgia Halladay
  855. Peter Harding
  856. Amie Reddy
  857. Ian Turner-Bone
  858. Laura Wilding
  859. Robert Parker
  860. Michaela Lloyd
  861. Leanne Smith
  862. Charlie Kelly
  863. Maria Lazo
  864. Alan Neal
  865. Olivia Walton
  866. Julie Melville
  867. Jay Naisbitt
  868. Emily Bullock
  869. Rosane Joseph
  870. Sara Callam
  871. Lisa Hudig
  872. Jocelyn Keshet-Price
  873. Katie Stammers
  874. Karen Convery
  875. Georgina Randell
  876. Deirdre Fottrell-Gould
  877. Esther Mwaura
  878. Sara-Beth Sutherland
  879. Richard Stewart
  880. Louise Mew
  881. Lynn Wren
  882. Laura Thrasyvoulou
  883. Heather Willis
  884. James Scriven
  885. Bridget Hopkins
  886. Daniel Lenton
  887. Abigail Roberts
  888. Maria Bokhari
  889. Rachael Lucas
  890. Wendy McCormick
  891. Jenny Ritzema
  892. Vanessa Linnett
  893. Amanda Sanderson
  894. Helen Wild
  895. Rebecca Flanagan
  896. Robert Hull
  897. Kat Rhead
  898. Emma McKenna
  899. Gareth Hughes
  900. Jennifer Anderson
  901. Kelly Jones
  902. Scott Latham
  903. Heather Riley
  904. Martina Coulding
  905. Martyn Clark
  906. Jacqueline McCormick
  907. Oliver Mercer
  908. Darsh Potla
  909. Hafiz Rehman
  910. Heather Savill
  911. Victoria Turner
  912. Edward Jude
  913. Susan Kilroy
  914. Elena Apetri
  915. Cathrine Basikolo
  916. Bethan Blackledge
  917. Laura Catlow
  918. Matthew Collis
  919. Reece Doonan
  920. Jade Harris
  921. Alice Harvey
  922. Karen Knowles
  923. Stephanie Lee
  924. Diane Lomas
  925. Chloe Lyons
  926. Liam McMorrow
  927. Angiy Michael
  928. Jessica Pendlebury
  929. Jane Perez
  930. Maria Poulaka
  931. Nicola Proudfoot
  932. Kathryn Slevin
  933. Vicky Thomas
  934. Danielle Walker
  935. Paul Dark
  936. Bethan Charles
  937. Danielle McLaughlan
  938. Melanie Slaughter
  939. Dan Horner
  940. Kathryn Cawley
  941. Tracy Marsden
  942. Joyann Andrews
  943. Emily Beech
  944. Olugbenga Akinkugbe
  945. Alasdair Bamford
  946. Holly Belfield
  947. Gareth A. L. Jones
  948. Tara McHugh
  949. Hamza Meghari
  950. Samiran Ray
  951. Ana Luisa Tomas
  952. Lauran O’Neill
  953. Mark Peters
  954. Michael Bell
  955. Sarah Benkenstein
  956. Catherine Chisholm
  957. Charlene Davies
  958. Klaudia Kupiec
  959. Caroline Payne
  960. Joanna Halls
  961. Hayley Blakemore
  962. Elizabeth Goff
  963. Kati Hayes
  964. Kerry Smith
  965. Deanna Stephens
  966. Ruth Worner
  967. Borislava Borislavova
  968. Beverley Faulkner
  969. Matt Thomas
  970. Ruth Cookson
  971. Emma Gendall
  972. Georgina Larman
  973. Rebecca Pope
  974. Artur Smalira
  975. Victoria Priestley
  976. Tracey Cosier
  977. Gemma Millen
  978. James Rand
  979. Natasha Schumacher
  980. Roxana Sandhar
  981. Heather Weston
  982. Neil Richardson
  983. Lucy Cooper
  984. Cathy Jones
  985. Ya-Wen Jessica Huang
  986. Reni Jacob
  987. Craig Denmade
  988. Lewis McIntyre
  989. Dawn Trodd
  990. Jane Martin
  991. Geoff Watson
  992. Emily Bevan
  993. Caroline Wreybrown
  994. Shereen Bano
  995. Ruth Bellwood
  996. Michael Bentley
  997. Matt Bromley
  998. Lucy Gurr
  999. Camilla Ledgard
  1000. Janet McGowan
  1001. Kate Pye
  1002. Kirsten Sellick
  1003. Amelia Stacey
  1004. Deborah Warren
  1005. Brian Wilkinson
  1006. Louise Akeroyd
  1007. Huma Shafique
  1008. James Morgan
  1009. Susan Shorter
  1010. Rachel Swinger
  1011. Emily Waters
  1012. Tom Lawton
  1013. Elizabeth Allan
  1014. Kate Darlington
  1015. Ffyon Davies
  1016. Llinos Davies
  1017. Jack Easton
  1018. Sumit Kumar
  1019. Richard Lean
  1020. Callum Mackay
  1021. Richard Pugh
  1022. Xinyi Qiu
  1023. Stephanie Rees
  1024. Jeremy Scanlon
  1025. Joanne Lewis
  1026. Daniel Menzies
  1027. Annette Bolger
  1028. Gwyneth Davies
  1029. Jennifer Davies
  1030. Esther Garrod
  1031. Helen Jones
  1032. Rachel Manley
  1033. Hannah Williams
  1034. Jordan Frankham
  1035. Sally Pitts
  1036. Nigel White
  1037. Debbie Branney
  1038. Heather Tiller
  1039. Georgia Efford
  1040. Zoe Garland
  1041. Lisa Grimmer
  1042. Bethany Gumbrill
  1043. Rebekah Johnson
  1044. Katie Sweet
  1045. Jeremy Bewley
  1046. Christina Coleman
  1047. Katie Corcoran
  1048. Eva Maria Hernandez Morano
  1049. Rachel Shiel
  1050. Denise Webster
  1051. Josephine Bonnici
  1052. Eleanor Daniel
  1053. Abbie Dell
  1054. Melanie Kent
  1055. Ami Wilkinson
  1056. Ellen Brown
  1057. Andrea Kay
  1058. Suzanne Campbell
  1059. Amanda Cowton
  1060. Mark Birt
  1061. Vicki Greenaway
  1062. Kathryn Potts
  1063. Clare Hutton
  1064. Andrew Shepperson
  1065. Miranda Forsey
  1066. Alice Nicholson
  1067. Mark Vertue
  1068. Joanne Riches
  1069. Agilan Kaliappan
  1070. Anne Nicholson
  1071. Niall MacCallum
  1072. Eamon Raith
  1073. Georgia Bercades
  1074. Ingrid Hass
  1075. David Brealey
  1076. Gladys Martir
  1077. Anna Reyes
  1078. Deborah Smyth
  1079. Maria Zapatamartinez
  1080. Ana Alvaro
  1081. Champa Jetha
  1082. Louise Ma
  1083. Lauren Booker
  1084. Loreta Mostoles
  1085. Anezka Pratley
  1086. Abdelhakim Altabaibeh
  1087. Chetan Parmar
  1088. Kayleigh Gilbert
  1089. Susie Ferguson
  1090. Amy Shepherd
  1091. Sheila Morris
  1092. Jo Singleton
  1093. Rosie Baruah
  1094. Maria Amamio
  1095. Sophie Birch
  1096. Kate Briton
  1097. Sarah Clark
  1098. Katherine Doverman
  1099. Lucy Marshall
  1100. Scott Simpson
  1101. Georgina Lloyd
  1102. Stephanie Bell
  1103. Vanessa Rivers
  1104. Bally Purewal
  1105. Kate Hammerton
  1106. Susan Anderson
  1107. Janine Birch
  1108. Emma Collins
  1109. Ryan Oleary
  1110. Sarah Cornell
  1111. Jordan Jarmain
  1112. Kimberley Rogerson
  1113. Fiona Wakinshaw
  1114. Lindsey Woods
  1115. Anthony Rostron
  1116. Zeynep Elcioglu
  1117. Alistair Roy
  1118. Gillian Bell
  1119. Holly Dickson
  1120. Louise Wilcox
  1121. Amro Katary
  1122. Katy English
  1123. Joanne Hutter
  1124. Corinne Pawley
  1125. Patricia Doble
  1126. Charmaine Shovelton
  1127. Marius Vaida
  1128. Rebecca Purnell
  1129. Ashly Thomas
  1130. Lenka Cagova
  1131. Adama Fofano
  1132. Helen Holcombe
  1133. Alice Michael Mitchell
  1134. Lucy Mwaura
  1135. Krithivasan P. Raman
  1136. Lucie Garnr
  1137. Sue Mepham
  1138. Kitty Paques
  1139. Alain Vuylsteke
  1140. Jennifer Mackie
  1141. Carmen Pearn
  1142. Julie Zamikula
  1143. Mark Birt
  1144. Estefania Treus Gude
  1145. Maggie Nyirenda
  1146. Lisa Capozzi
  1147. Rosie Reece-Anthony
  1148. Waqas Khaliq
  1149. Hazma Noor
  1150. Alfa Cresia Nilo
  1151. Michelle Grove
  1152. Amelia Daniel
  1153. Amy Easthope
  1154. Joanne Finn
  1155. Nikki White
  1156. Rajnish Saha
  1157. Bibi Badal
  1158. Karen Ixer
  1159. Donna Duffin
  1160. Ben Player
  1161. Helen Hill
  1162. Jade Cole
  1163. Jenny Brooks
  1164. Michelle Davies
  1165. Rhys Davies
  1166. Lauren Hunt
  1167. Emma Thomas
  1168. Angharad Williams
  1169. Metod Oblak
  1170. Mini Thankachen
  1171. Jamie Irisari
  1172. Amrinder Sayan
  1173. Monica Popescu
  1174. Cheryl Finch
  1175. Andrew Jamieson
  1176. Alison Quinn
  1177. Joshua Cooper
  1178. Sarah Liderth
  1179. Natalia Waddington
  1180. Iona Burn
  1181. Katarina Manso
  1182. Ruth Penn
  1183. Julie Tebbutt
  1184. Danielle Thornton
  1185. James Winchester
  1186. Geraldine Hambrook
  1187. Pradeep Shanmugasundaram
  1188. Jayne Craig
  1189. Kerry Simpson
  1190. Andrew Higham
  1191. Louise Sibbett
  1192. Sheila Paine
  1193. Annabel Reed
  1194. Jo-Anna Conyngham
  1195. McDonald Mupudzi
  1196. Rachel Thomas
  1197. Mary Wright
  1198. Denise Griffin
  1199. Richard Partridge
  1200. Maria Alvarez Corral
  1201. Nycola Muchenje
  1202. Mildred Sitonik
  1203. Caroline Wrey Brown
  1204. Aaron Butler
  1205. Linda Folkes
  1206. Heather Fox
  1207. Amy Gardner
  1208. David Helm
  1209. Gillian Hobden
  1210. Kirsten King
  1211. Jordi Margalef
  1212. Michael Margarson
  1213. Tim Martindale
  1214. Emma Meadows
  1215. Dana Raynard
  1216. Yvette Thirlwall
  1217. Yolanda Baird
  1218. Raquel Gomez
  1219. Darren Martin
  1220. Luke Hodgson
  1221. Clinton Corin
  1222. Erikka Sidall
  1223. Densie Szabo
  1224. Sharon Floyd
  1225. Hannah Davies
  1226. Karen Austin
  1227. Olivia Kelsall
  1228. Hannah Wood
  1229. Peter Anderson
  1230. Katie Archer
  1231. Andrew Burtenshaw
  1232. Sarah Clayton
  1233. Naiara Cother
  1234. Nicholas Cowley
  1235. Caroline Davis
  1236. Stephen Digby
  1237. Alison Durie
  1238. Alison Harrison
  1239. Emma Low
  1240. Michael McAlindon
  1241. Alex McCurdy
  1242. Aled Morgan
  1243. Tobias Rankin
  1244. Jessica Thrush
  1245. Helen Tranter
  1246. Charlie Vigurs
  1247. Laura Wild
  1248. Thomas Cornell
  1249. Kate Ralph
  1250. Sarah Bean
  1251. Karen Burt
  1252. Michael Spivey
  1253. Carol Richards
  1254. Rachel Tedstone
  1255. Siobhain Carmody
  1256. Xiaobei Zhao
  1257. Valerie Page
  1258. Mark Louie Guanco
  1259. Elvira Hoxha
  1260. Camilla Zorloni
  1261. Charlotte Dean
  1262. Emma Jones
  1263. Emma Carter
  1264. Joshua Dunn
  1265. Thomas Kong
  1266. Mervin Mahenthran
  1267. Chris Marsh
  1268. Maureen Holland
  1269. Natalie Keenan
  1270. Mohamed Mahmoud
  1271. Marc Lyons
  1272. Joanne Bradley-Potts
  1273. Helen Wassall
  1274. Meghan Young
  1275. Paul Bradley
  1276. Dorota Burda
  1277. Sinead Donlon
  1278. Lesley Harden
  1279. Celia Harris
  1280. Irving Mayangao
  1281. Rugia Montaser
  1282. Sheila Mtuwa
  1283. Charles Piercy
  1284. Eleanor Smith
  1285. Sarah Stone
  1286. Jerik Verula
  1287. Helen Blackman
  1288. Cheryl Marriott
  1289. Natalia Michalak
  1290. Ben Creagh-Brown
  1291. Armorel Salberg
  1292. Naomi Boyer
  1293. Veronika Pristopan
  1294. Victoria Maynard
  1295. Rachel Walker
  1296. Anil Hormis
  1297. Dawn Collier
  1298. Cheryl Graham
  1299. Vicky Maynard
  1300. Jake McCormick
  1301. Jake Warrington
  1302. Denise Cosgrove
  1303. Denise McFarland
  1304. Judith Ratcliffe
  1305. Rob Charnock
  1306. Inez Wynter
  1307. Mandy Gill
  1308. Jill Kirk
  1309. Paul Paul
  1310. Valli Ratnam
  1311. Sarah Shelton
  1312. Catherine Jardine
  1313. Alasdair Hay
  1314. Dewi Williams
  1315. Bethan Deacon
  1316. Latha Durga
  1317. Meg Hibbert
  1318. Gareth Kennard-Holden
  1319. Chrsitopher Woodford
  1320. Carla Pothecary
  1321. Lisa Roche
  1322. Dariusz Tetla
  1323. Kevin Agravante
  1324. Justyna Smeaton
  1325. Alicia Price
  1326. Alice Thomas
  1327. Chris Thorpe
  1328. Ellen Knights
  1329. Donna Ward
  1330. Shondipon Laha
  1331. Mark Verlander
  1332. Alexandra Williams
  1333. Rachel Prout
  1334. Helen Langton
  1335. Malcolm Watters
  1336. Charlotte Hunt
  1337. Catherine Novis
  1338. Sarwat Arif
  1339. Amy Cunningham
  1340. Claire Hewitt
  1341. Julia Hindale
  1342. Karen Jackson-Lawrence
  1343. Sarah Shepardson
  1344. Maryanne Wills
  1345. Susie Butler
  1346. Silivia Tavares
  1347. Russell Barber
  1348. Annette Hilldrith
  1349. Kelly Hubbard
  1350. Dawn Egginton
  1351. Michele Clark
  1352. Sarah Purvis
  1353. Simon Sinclair
  1354. Vicky Collins
  1355. Bethan Landeg
  1356. Craig Sell
  1357. Samantha Coetzee
  1358. Alistair Gales
  1359. Igor Otahal
  1360. Becky Icke
  1361. Meena Raj
  1362. Caroline Williams
  1363. Jill Williams
  1364. Lucy Hill
  1365. Abdul Kayani
  1366. Bridgett Masunda
  1367. Prisca Gondo
  1368. Nigara Atayeva
  1369. Carina Cruz
  1370. Natalie Pattison
  1371. Caroline Burnett
  1372. Jonathan Hatton
  1373. Elaine Heeney
  1374. Maria Newton
  1375. Hassan Al-Moasseb
  1376. Teresa Behan
  1377. Jasmine Player
  1378. Rachael Stead
  1379. Atideb Mitra
  1380. Kirsty Nauyokas
  1381. Sally Humphreys
  1382. Helen co*ckerill
  1383. Ruth Tampsett
  1384. Evgeniya Postovalova
  1385. Tina Coventry
  1386. Amanda McGregor
  1387. Susan Fowler
  1388. Mike Macmahon
  1389. Patricia Cochrane
  1390. Sandra Pirie
  1391. Sarah Hanley
  1392. Asifa Ali
  1393. Megan Brady
  1394. Sam Dale
  1395. Annalisa Dance
  1396. Lisa Gledhill
  1397. Jill Greig
  1398. Kathryn Hanson
  1399. Kelly Holdroyd
  1400. Marie Home
  1401. Tahira Ishaq
  1402. Diane Kelly
  1403. Lear Matapure
  1404. Deborah Melia
  1405. Samantha Mellor
  1406. Ekta Merwaha
  1407. Tonicha Nortcliffe
  1408. Lisa Shaw
  1409. Ryan Shaw
  1410. Tracy Wood
  1411. Lee-Ann Bayo
  1412. Miranda Usher
  1413. Alison Wilson
  1414. Ross Kitson
  1415. Jez Pinnell
  1416. Matthew Robinson
  1417. Kaitlin Boltwood
  1418. Jenny Birch
  1419. Laura Bough
  1420. Rebecca Tutton
  1421. Barbara Winter-Goodwin
  1422. Josie Goodsell
  1423. Kate Taylor
  1424. Patricia Williams
  1425. Sarah Williams
  1426. Ashleigh Cave
  1427. James Rees
  1428. Janet Imeson-Wood
  1429. Jacqueline Smith
  1430. Vishal Amin
  1431. Komala Karthik
  1432. Rizwana Kausar
  1433. Elena Anastasescu
  1434. Karen Reid
  1435. Vikram Anumakonda
  1436. Ella Stoddart
  1437. Carrie Demetriou
  1438. Charlotte Eckbad
  1439. Lucy Howie
  1440. Sarah Mitchard
  1441. Lidia Ramos
  1442. Katie White
  1443. Sarah Hierons
  1444. Fiona Kelly
  1445. Alfredo Serrano-Ruiz
  1446. Gabrielle Evans
  1447. Liz Nicol
  1448. Joy Wilkins
  1449. Kim Hulacka
  1450. Gabor Debreceni
  1451. Alison Brown
  1452. Vikki Crickmore
  1453. Kay Hill
  1454. Thogulava Kannan
  1455. Zenaida Dagutao
  1456. Kate Beesley
  1457. Alison Lewis
  1458. Jess Perry
  1459. Sherly Antony
  1460. Sarah Board
  1461. Clare Buckley
  1462. Lucy Pippard
  1463. Alfonso Tanate
  1464. Diane Wood
  1465. Agnieska Kubisz-Pudelko
  1466. Ayman Gouda
  1467. Fiona Auld
  1468. Joanne Donnachie
  1469. Euan Murdoch
  1470. Lynn Prentice
  1471. Nikole Runciman
  1472. Dhaneesha Senaratne
  1473. Abigail Short
  1474. Laura Sweeney
  1475. Lesley Symon
  1476. Anne Todd
  1477. Patricia Turner
  1478. Erin McCann
  1479. Dario Salutous
  1480. Ian Edmond
  1481. Lesley Whitelaw
  1482. Harish Venkatesh
  1483. Yvonne Bland
  1484. Istvan Kajtor
  1485. Lisa Kavanagh
  1486. Karen Singler
  1487. George Linfield-Brown
  1488. Luke Stephen Prockter Moore
  1489. Marcela Vizcaychipi
  1490. Laura Martins
  1491. Luke Moore
  1492. Rhian Bull
  1493. Jaime Carungcong
  1494. Louise Allen
  1495. Eva Beranova
  1496. Alicia Knight
  1497. Carly Price
  1498. Sorrell Tilbey
  1499. Sharon Turney
  1500. Tracy Hazelton
  1501. Gabriella Tutt
  1502. Mansi Arora
  1503. Salah Turki
  1504. Emily Sinfield
  1505. Joanne Deery
  1506. Hazel Ramos
  1507. Daniele Cristiano
  1508. Natalie Dormand
  1509. Zohreh Farzad
  1510. Mahitha Gummadi
  1511. Sara Salmi
  1512. Geraldine Sloane
  1513. Mathew Varghese
  1514. Vicky Thwaites
  1515. Brijesh Patel
  1516. Liyanage Kamal
  1517. Anelise Catelan Zborowski
  1518. Ryan Coe
  1519. Madeleine Anderson
  1520. Jane Beadle
  1521. Charlotte Coates
  1522. Katy Collins
  1523. Maria Crowley
  1524. Laura Johnson
  1525. Laura King
  1526. Remi Paramsothy
  1527. Janet Sargeant
  1528. Pedro Silva
  1529. Carmel Stuart
  1530. June Taylor
  1531. David Tyl
  1532. Phillipa Wakefield
  1533. Charlotte Kamundi
  1534. Olumide Olufuwa
  1535. Zakaulla Belagodu
  1536. Anca Gherman
  1537. Naomi Oakley
  1538. John Allan
  1539. Tim Geary
  1540. Alistair Meikle
  1541. Peter O’Brien
  1542. Stephen Wood
  1543. Andrew Clark
  1544. Gordon Houston
  1545. Karen Black
  1546. Michelle Clarkson
  1547. Stuart D’Sylva
  1548. Alan Morrison
  1549. Kathryn Norman
  1550. Margaret Taylor
  1551. Suzanne Clements
  1552. Catriona Cohrane
  1553. Nora Gonzalez
  1554. Dominic Strachan
  1555. Claire Beith
  1556. Kirsten Moar
  1557. Lorna Murphy
  1558. Michelle Smythe
  1559. Alistair Nichol
  1560. Kathy Brickell
  1561. Inthakab Ali Mohamed Ali
  1562. Karen Beaumont
  1563. Mohamed Elsaadany
  1564. Kay Fernandes
  1565. Sameena Mohamed Ally
  1566. Harini Rangarajan
  1567. Varun Sarathy
  1568. Sivarupan Selvanayagam
  1569. Dave Vedage
  1570. Matthew White
  1571. Zoe Coton
  1572. Aricsa Joshy
  1573. Mark Blunt
  1574. Hollie Curgenven
  1575. Liam Botfield
  1576. Catherine Dexter
  1577. Aditya Kuravi
  1578. Joanne Butler
  1579. Robert Chadwick
  1580. Poonam Ranga
  1581. Lisa Richardson
  1582. Emma Virgilio
  1583. Maddiha Anwer
  1584. Atul Garg
  1585. Donna Botfield
  1586. Xana Marriott
  1587. Keely Stewart
  1588. Dee Mullan
  1589. Claire Phillips
  1590. Jane Gaylard
  1591. Justyna Nowak
  1592. Denise Skinner
  1593. Sian Jones
  1594. Rikki Crawley
  1595. Abigail Crew
  1596. Mishell Cunningham
  1597. Allison Daniels
  1598. Laura Harrison
  1599. Susan Hope
  1600. Nicola Lancaster
  1601. Jamie Matthews
  1602. Gemma Wray
  1603. Alice Nicholson
  1604. Ken Inweregbu
  1605. Sarah Cutts
  1606. Katharine Miller
  1607. Ailbhe Brady
  1608. Rebekah Chan
  1609. Shane McIvor
  1610. Helena Prady
  1611. Bijoy Mathew
  1612. Jeff Little
  1613. Tim Furniss
  1614. Chris Wright
  1615. Bernadette King
  1616. Christopher Wasson
  1617. Aisling O’Neill
  1618. Christine Turley
  1619. Peter McGuigan
  1620. Erin Collins
  1621. Stephanie Finn
  1622. Jackie Green
  1623. Julie McAuley
  1624. Abitha Nair
  1625. Charlotte Quinn
  1626. Suzanne Tauro
  1627. Kathryn Ward
  1628. Michael McGinlay
  1629. Kiran Reddy
  1630. Norfaizan Ahmad
  1631. Samantha Anderson
  1632. Joann Barker
  1633. Kris Bauchmuller
  1634. Kathryn Birchall
  1635. Sarah Bird
  1636. Kay Cawthron
  1637. Luke Chetam
  1638. Joby Cole
  1639. Ben Donne
  1640. David Foote
  1641. Amber Ford
  1642. Helena Hanratty
  1643. Kate Harrington
  1644. Lisa Hesseldon
  1645. Kay Housley
  1646. Yvonne Jackson
  1647. Claire Jarman
  1648. Faith Kibutu
  1649. Becky Lenagh
  1650. Irene Macharia
  1651. Shamiso Masuko
  1652. Leanne Milner
  1653. Helen Newell
  1654. Lorenza Nwafor
  1655. Simon Oxspring
  1656. Patrick Phillips
  1657. Ajay Raithatha
  1658. Sarah Rowland-Jones
  1659. Jacqui Smith
  1660. Roger Thompson
  1661. Helen Trower
  1662. Sara Walker
  1663. James Watson
  1664. Matthew Wiles
  1665. Alison Lye
  1666. Jayne Willson
  1667. Gary Mills
  1668. Sansha Harris
  1669. Eleanor Hartill
  1670. Anthony Barron
  1671. Ciara Collins
  1672. Sundeep Kaul
  1673. Claire Nolan
  1674. Oliver Polgar
  1675. Claire Prendergast
  1676. Paula Rogers
  1677. Rajvinder Shokkar
  1678. Meriel Woodruff
  1679. Kanta Mahay
  1680. Vicky Thwaites
  1681. Anna Reed
  1682. Hayley Meyrick
  1683. Heather Passmore
  1684. James Farwell
  1685. Alison Brown
  1686. Susan O’Connell
  1687. Jane Gregory
  1688. Luigi Barberis
  1689. Rosemary Harper
  1690. Tim Smith
  1691. Diane Armstrong
  1692. Angie Bowey
  1693. Anne Cowley
  1694. Andrew Corner
  1695. Judith Highgate
  1696. Claire Rutherfurd
  1697. Jo-Anne Taylor
  1698. Sarah Goodwin
  1699. Claire Rutherford
  1700. Beena Eapen
  1701. Fiona Trim
  1702. Phil Donnison
  1703. Lisa Armstrong
  1704. Hayley Bates
  1705. Emma Dooks
  1706. Fiona Farquhar
  1707. Amy Kitching
  1708. Chantal McParland
  1709. Sophie Packham
  1710. Brigid Hairsine
  1711. Anand Patil
  1712. Premetie Andreou
  1713. Dawn Hales
  1714. Megha Mathews
  1715. Rekha Patel
  1716. Peter Barry
  1717. Neil Flint
  1718. Jessica Hailstone
  1719. Navneet Ghuman
  1720. Bethany Leonard
  1721. Rachel Lees
  1722. Deborah Butcher
  1723. Katy Leng
  1724. Nicola Butterworth-Cowin
  1725. Susie O’Sullivan
  1726. Alison Ghosh
  1727. Emma Williams
  1728. Colene Adams
  1729. Anita Agasou
  1730. Tracie Arden
  1731. Mandy Beekes
  1732. Amy Bowes
  1733. Pauline Boyle
  1734. Heather Button
  1735. Mandy Carnahan
  1736. Anne Carter
  1737. Danielle Childs
  1738. Jane Gaylard
  1739. Fran Hurford
  1740. Yasmin Hussain
  1741. Ayesha Javaid
  1742. James Jones
  1743. Michael Leigh
  1744. Terry Martin
  1745. Helen Millward
  1746. Nichola Motherwell
  1747. Dee Mullan
  1748. Julie Newman
  1749. Rachel Rikunenko
  1750. Jo Stickley
  1751. Julie Summers
  1752. Louise Ting
  1753. Helen Tivenan
  1754. Denise Donaldson
  1755. Nigel Capps
  1756. Emily Cale
  1757. Sanal Jose
  1758. Wendy Osbourne
  1759. Susie Pajak
  1760. Jayne Rankin
  1761. Louise Tonks
  1762. Tracy Baird
  1763. Margaret Harkins
  1764. Jim Ruddy
  1765. Joe West
  1766. Joseph Duffield
  1767. Lewis Mallon
  1768. Oliver Smith
  1769. Sara Smuts
  1770. Andy Campbell
  1771. Cate Davies
  1772. Sarah Davies
  1773. Rachel Hughes
  1774. Lisa Jobes
  1775. Victoria Whitehead
  1776. Clare Watkins
  1777. Fiona Bowman
  1778. Barry Milligan
  1779. Liane McPherson
  1780. Stella Metherell
  1781. Nichola Harris
  1782. Victoria Lake
  1783. Elizabeth Radford
  1784. Andy Smallwood
  1785. Shameer Gopal
  1786. Katherine Vassell
  1787. Dina Bell
  1788. Rosalind Boyle
  1789. Katie Douglas
  1790. Lynn Glass
  1791. Liz Lennon
  1792. Austin Rattray
  1793. Claire Beith
  1794. Emma Lee
  1795. Danielle Jones
  1796. Penny Parsons
  1797. Ben Attwood
  1798. Paul Jefferson
  1799. Mohan Ranganathan
  1800. Inderjit Atwal
  1801. Bridget Campbell
  1802. Angela Day
  1803. Camilla Stagg
  1804. Emma Haynes
  1805. Cecilia Ahmed
  1806. Sarah Clamp
  1807. Julie Colley
  1808. Risna Haq
  1809. Anne Hayes
  1810. Sibet Joseph
  1811. Zahira Maqsood
  1812. Samia Hussain
  1813. Jonathan Hulme
  1814. Patience Domingos
  1815. Rita Kumar
  1816. Manjit Purewal
  1817. Becky Taylor
  1818. Lara Bunni
  1819. Monica Latif
  1820. Claire Jennings
  1821. Shilu Jose
  1822. Rebecca Marshall
  1823. Aleksandra Metryka
  1824. Gayathri Subramanian
  1825. Adam Burgoyne
  1826. Susan O’Connell
  1827. Amanda Tyler
  1828. Joanne Waldron
  1829. Paula Hilltout
  1830. Jayne Evitts
  1831. Geraldine Ward
  1832. Pamela Bremmer
  1833. Carl Hawkins
  1834. Sophie Jackman
  1835. Michal Ogorek
  1836. Kylie Ashby
  1837. Lorraine Thornton
  1838. Pauline Mercer
  1839. Matthew Halkes
  1840. Adam Revill
  1841. Bryony Saint
  1842. Jo Fletcher
  1843. Kimberley Netherton
  1844. Manish Chablani
  1845. Amy Kirkby
  1846. Amanda Roper
  1847. Kinga Szymiczek
  1848. Isobel Sutherland
  1849. Linda O’Brien
  1850. Igor Otahal
  1851. Joanne Connell
  1852. Kim Davies
  1853. Tracy Lewis
  1854. Zohra Omar
  1855. Emma Perkins
  1856. Lisa Roche
  1857. Sonia Sathe
  1858. Ellie Davies
  1859. Alex Lyon
  1860. Isheunesu Mapfunde
  1861. Charlotte Willis
  1862. Rachael Hitchco*ck
  1863. Kathryn Hall
  1864. Christopher King
  1865. Andrew fa*gan
  1866. Roonak Nazari
  1867. Lucy Worsley
  1868. Suzanne Allibone
  1869. Vidya Kasipandian
  1870. Amit Patel
  1871. Parisa Cutting
  1872. Roman Genetu
  1873. Ainhi Mac
  1874. Anthony Murphy
  1875. Sinead Ward
  1876. Fatima Butt
  1877. Amanda Ayers
  1878. Wendy Harrison
  1879. Katherine Mackintosh
  1880. Julie North
  1881. Lydia Ashton
  1882. Rehana Bi
  1883. Samantha Owen
  1884. Helen Winmill
  1885. Barney Scholefield
  1886. Hannah Blowing
  1887. Erin Williams
  1888. Michaela Duskova
  1889. Michelle Edwards
  1890. Alun Rees
  1891. Helen Thomas
  1892. Rachel Hughes
  1893. Igor Otahal
  1894. Jolene Brooks
  1895. Janet Phipps
  1896. Suzanne Brooks
  1897. Catherine Dennis
  1898. Vicki Parris
  1899. Sinduya Srikaran
  1900. Anisha Sukha
  1901. Alistair McGregor
  1902. Gerlynn Tiongson
  1903. Katie Adams
  1904. Benedict Andrew
  1905. Adam Brayne
  1906. Sasha Carter
  1907. Louise Findlay
  1908. Emma Fisher
  1909. Peter Jackson
  1910. Duncan Kaye
  1911. Juliet Parkin
  1912. Victoria Tuckey
  1913. Jane Hunt
  1914. Nicholas Love
  1915. Lynne van Koutrick
  1916. Ashley Hanson
  1917. Kathy Dent
  1918. Elizabeth Horsley
  1919. Sandra Pearson
  1920. Sue Spencer
  1921. Dorothy Hutchinson
  1922. Jasmine Player
  1923. Dorota Potoczna
  1924. Muhammad Nauman Akhtar
  1925. Lisa-Jayne Cottam
  1926. Kirsty Nauyokas
  1927. Jack Sanders
  1928. Sara Mingo Garcia
  1929. Glykeria Pakou
  1930. Cynthia Diaba
  1931. Helder Filipe
  1932. Lincy John
  1933. Amitaa Maharajh
  1934. Mark de Neef
  1935. Daniel Martin
  1936. Christine Eastgate
  1937. Poh Choo Teoh
  1938. Fiona Barrett
  1939. Clare Bradley
  1940. Avril Donaldson
  1941. Mairi Mascarenhas
  1942. Marianne O’Hara
  1943. Laura Okeefe
  1944. Noreen Clarke
  1945. Jonathan Whiteside
  1946. Rachael Campbell
  1947. Joanna Matheson
  1948. Deborah McDonald
  1949. Donna Patience
  1950. Polly Rice
  1951. Tim Smith
  1952. Melanie Clapham
  1953. Rachel Mutch
  1954. Luigi Barberis
  1955. Rosemary Harper
  1956. Hannah Craig
  1957. Una Poultney
  1958. Karen Burns
  1959. Andrew Higham
  1960. Sophie Twiss
  1961. Janet Barton
  1962. Linsha George
  1963. Clare Harrop
  1964. Sherly Mathew
  1965. David Justin Wright
  1966. Rachel Harrison
  1967. Jordan Toohie
  1968. Ben Chandler
  1969. Alison Turnbull
  1970. Janine Mallinson
  1971. Kerry Elliott
  1972. Rebecca Wolf-Roberts
  1973. Helen Tench
  1974. Igor Otahal
  1975. Maria Hobrok
  1976. Ronda Loosley
  1977. Heather McGuinness
  1978. Tanya Sims
  1979. Deborah Afolabi
  1980. Kathryn Sian Allison
  1981. Taya Anderson
  1982. Rachael Dore
  1983. Dawn Jones
  1984. Naomi Rogers
  1985. Paula Saunderson
  1986. Jennifer Whitbread
  1987. Laura O’Malley
  1988. Laura Rad
  1989. Daniel Hawcutt
  1990. Jonathan Aldridge
  1991. Melanie Tolson
  1992. Sweyn Garrioch
  1993. Joanne Tomlinson
  1994. Michael Grosdenier
  1995. David Loader
  1996. Ritoo Kapoor
  1997. Gemma Hector
  1998. Joslan Scherewode
  1999. Chunda Sri-Chandana
  2000. Lorraine Stephenson
  2001. Sarah Marsh
  2002. Arnold Dela Rosa
  2003. Shaman Jhanji
  2004. Thomas Bemand
  2005. Ryan Howle
  2006. Ravishankar Rao Baikady
  2007. Benjamin Thomas
  2008. Ethel Black
  2009. Kate Tatham
  2010. Sambasivarao Gurram
  2011. Ekaterina Watson
  2012. Vicki Parris
  2013. Sheena Quaid
  2014. Alistair McGregor
  2015. Anne Saunderson
  2016. Rachel O’Brien
  2017. Sam Moultrie
  2018. Jen Service
  2019. Clare Cheyne
  2020. Miranda Odam
  2021. Alison Wiliams
  2022. Nicky Barnes
  2023. Peter Csabi
  2024. Joana Da Rocha
  2025. Louika Glynou
  2026. Amy Huffenberger
  2027. Jade Bryant
  2028. Amy Pickard
  2029. Nicholas Roe
  2030. Arianna Bellini
  2031. Anton Mayer
  2032. Amy Burrow
  2033. Natalie Colley
  2034. Jayne Evans
  2035. Alex Howlett
  2036. Zeinab Khalifeh
  2037. Jerldine Pryce
  2038. Claire Gorman
  2039. Amy Easthope
  2040. Rebecca Brady
  2041. Elizabeth Timlick
  2042. Pierre Antoine
  2043. Abhinhav Gupta
  2044. John Hardy
  2045. Henry Houlden
  2046. Eleanor Moncur
  2047. Arianna Tucci
  2048. Eamon Raith
  2049. Ambreen Tariq
  2050. David Brealey
  2051. Emma Tagliavini
  2052. Becky Ramsay
  2053. Katy Fidler
  2054. Kevin Donnelly
  2055. Rebecca Hollis
  2056. Jocelyn Barr
  2057. Elizabeth Boyd
  2058. Val Irvine
  2059. Ben Shelley
  2060. Julie Buckley
  2061. Charlene Hamilton
  2062. Kathryn Valdeavella
  2063. Javier Abellan
  2064. René Acosta-Isaac
  2065. Jose María Aguado
  2066. Carlos Aguilar
  2067. Sergio Aguilera-Albesa
  2068. Abdolah Ahmadi Sabbagh
  2069. Jorge Alba
  2070. Sergiu Albu
  2071. Karla A. M. Alcalá-Gallardo
  2072. Julia Alcoba-Florez
  2073. Sergio Alcolea Batres
  2074. Holmes Rafael Algarin-Lara
  2075. Virginia Almadana
  2076. Julia Almeida
  2077. Berta Almoguera
  2078. María R. Alonso
  2079. Nuria Alvarez
  2080. Yady Álvarez-Benítez
  2081. Felipe Álvarez-Navia
  2082. Rodolfo Alvarez-Sala Walther
  2083. Álvaro Andreu-Bernabeu
  2084. Maria Rosa Antonijoan
  2085. Eunate Arana-Arri
  2086. Carlos Aranda
  2087. Celso Arango
  2088. Carolina Araque
  2089. Nathalia K. Araujo
  2090. Izabel M. T. Araujo
  2091. Ana C. Arcanjo
  2092. Ana Arnaiz
  2093. Francisco Arnalich Fernández
  2094. María J. Arranz
  2095. José Ramon Arribas Lopez
  2096. Maria-Jesus Artiga
  2097. Yubelly Avello-Malaver
  2098. Carmen Ayuso
  2099. Ana Margarita Baldión-Elorza
  2100. Belén Ballina Martín
  2101. Raúl C. Baptista-Rosas
  2102. Andrea Barranco-Díaz
  2103. María Barreda-Sánchez
  2104. Viviana Barrera-Penagos
  2105. Moncef Belhassen-Garcia
  2106. Enrique Bernal
  2107. David Bernal-Bello
  2108. Joao F. Bezerra
  2109. Marcos A. C. Bezerra
  2110. Natalia Blanca-López
  2111. Rafael Blancas
  2112. Lucía Boix-Palop
  2113. Alberto Borobia
  2114. Elsa Bravo
  2115. María Brion
  2116. Óscar Brochado-Kith
  2117. Ramón Brugada
  2118. Matilde Bustos
  2119. Alfonso Cabello
  2120. Juan J. Caceres-Agra
  2121. Esther Calbo
  2122. Enrique J. Calderón
  2123. Shirley Camacho
  2124. Marcela C. Campos
  2125. Yolanda Cañadas
  2126. Cristina Carbonell
  2127. Servando Cardona-Huerta
  2128. Antonio Augusto F. Carioca
  2129. Maria Sanchez Carpintero
  2130. Carlos Carpio Segura
  2131. Thássia M. T. Carratto
  2132. José Antonio Carrillo-Avila
  2133. Maria C. C. Carvalho
  2134. Carlos Casasnovas
  2135. Luis Castano
  2136. Carlos F. Castaño
  2137. Jose E. Castelao
  2138. Aranzazu Castellano Candalija
  2139. María A. Castillo
  2140. Francisco C. Ceballos
  2141. Jessica G. Chaux
  2142. Walter G. Chaves-Santiago
  2143. Sylena Chiquillo-Gómez
  2144. Marco A. Cid-Lopez
  2145. Oscar Cienfuegos-Jimenez
  2146. Rosa Conde-Vicente
  2147. M. Lourdes Cordero-Lorenzana
  2148. Dolores Corella
  2149. Almudena Corrales
  2150. Jose L. Cortes-Sanchez
  2151. Marta Corton
  2152. Tatiana X. Costa
  2153. Raquel Cruz
  2154. Marina S. Cruz
  2155. Luisa Cuesta
  2156. Gabriela C. R. Cunha
  2157. Gabriela V. da Silva
  2158. David Dalmau
  2159. Raquel C. S. Dantas-Komatsu
  2160. M. Teresa Darnaude
  2161. Raimundo de Andrés
  2162. Jéssica N. G. de Araújo
  2163. Carmen de Juan
  2164. Juan De la Cruz Troca
  2165. Carmen de la Horra
  2166. Ana B. de la Hoz
  2167. Alba De Martino-Rodríguez
  2168. Julianna Lys de Sousa Alves Neri
  2169. Victor del Campo-Pérez
  2170. Juan Delgado-Cuesta
  2171. Covadonga M. Diaz-Caneja
  2172. Anderson Díaz-Pérez
  2173. Aranzazu Diaz de Bustamante
  2174. Beatriz Dietl
  2175. Silvia Diz-de Almeida
  2176. Manoella do Monte Alves
  2177. Elena Domínguez-Garrido
  2178. Katiusse A. dos Santos
  2179. Alice M. Duarte
  2180. Jose Echave-Sustaeta
  2181. Rocío Eiros
  2182. César O. Enciso-Olivera
  2183. Gabriela Escudero
  2184. Pedro Pablo España
  2185. Gladys Mercedes Estigarribia Sanabria
  2186. María Carmen Fariñas
  2187. Marianne R. Fernandes
  2188. Ramón Fernández
  2189. Lidia Fernandez-Caballero
  2190. Ana Fernández-Cruz
  2191. María J. Fernandez-Nestosa
  2192. Uxía Fernández-Robelo
  2193. Amanda Fernández-Rodríguez
  2194. Marta Fernández-Sampedro
  2195. Ruth Fernández-Sánchez
  2196. Tania Fernández-Villa
  2197. Silvia Fernández Ferrero
  2198. Yolanda Fernández Martínez
  2199. Carmen Fernéndez Capitán
  2200. Patricia Flores-Pérez
  2201. Vicente Friaza
  2202. Lácides Fuenmayor-Hernández
  2203. Marta Fuertes Núñez
  2204. Victoria Fumadó
  2205. Ignacio Gadea
  2206. Lidia Gagliardi
  2207. Manuela Gago-Domínguez
  2208. Natalia Gallego
  2209. Cristina Galoppo
  2210. Inés García
  2211. Mercedes García
  2212. Leticia García
  2213. Carlos Garcia-Cerrada
  2214. Aitor García-de-Vicuña
  2215. Josefina Garcia-García
  2216. Irene García-García
  2217. Carmen García-Ibarbia
  2218. Andrés C. García-Montero
  2219. Ana García-Soidán
  2220. Elisa García-Vázquez
  2221. María Carmen García Torrejón
  2222. Emiliano Garza-Frias
  2223. Angela Gentile
  2224. Belén Gil-Fournier
  2225. Javier Gómez-Arrue
  2226. Mario Gómez-Duque
  2227. Luis Gómez Carrera
  2228. María Gómez García
  2229. Ángela Gómez Sacristán
  2230. Anna González-Neira
  2231. Javier González-Peñas
  2232. Manuel Gonzalez-Sagrado
  2233. Beatriz González Álvarez
  2234. Fernan Gonzalez Bernaldo de Quirós
  2235. Hugo Gonzalo Benito
  2236. Oscar Gorgojo-Galindo
  2237. Miguel Górgolas
  2238. Florencia Guaragna
  2239. Genilson P. Guegel
  2240. Beatriz Guillen-Guio
  2241. Encarna Guillen-Navarro
  2242. Pablo Guisado-Vasco
  2243. Juan F. Gutiérrez-Bautista
  2244. Luz D. Gutierrez-Castañeda
  2245. Sarah Heili-Frades
  2246. Estefania Hernandez
  2247. Luis D. Hernandez-Ortega
  2248. Guillermo Hernández-Pérez
  2249. Rebeca Hernández-Vaquero
  2250. Cristina Hernández Moro
  2251. Belen Herraez
  2252. M. Teresa Herranz
  2253. María Herrera
  2254. María José Herrero
  2255. Antonio Herrero-Gonzalez
  2256. Juan P. Horcajada
  2257. Natale Imaz-Ayo
  2258. Maider Intxausti-Urrutibeaskoa
  2259. María Íñiguez
  2260. Rafael H. Jacomo
  2261. Rubén Jara
  2262. Perez Maria Jazmin
  2263. Ángel Jiménez
  2264. Pilar Jiménez
  2265. Ignacio Jiménez-Alfaro
  2266. María A. Jimenez-Sousa
  2267. Iolanda Jordan
  2268. Rocío Laguna-Goya
  2269. Daniel Laorden
  2270. María Lasa-Lazaro
  2271. María Claudia Lattig
  2272. Ailen Lauriente
  2273. Anabel Liger Borja
  2274. Lucía Llanos
  2275. Amparo López-Bernús
  2276. Esther Lopez-Garcia
  2277. Rosario Lopez-Rodriguez
  2278. Miguel A. López-Ruz
  2279. Eduardo López Granados
  2280. Leonardo Lorente
  2281. José E. Lozano
  2282. María Lozano-Espinosa
  2283. Andre D. Luchessi
  2284. Ignacio Mahillo
  2285. Esther Mancebo
  2286. Carmen Mar
  2287. Cristina Marcelo Calvo
  2288. Miguel Marcos
  2289. Alba Marcos-Delgado
  2290. Alicia Marín Candon
  2291. Pablo Mariscal Aguilar
  2292. María M. Martín
  2293. María Dolores Martín
  2294. Vicente Martín
  2295. Marta Martin-Fernandez
  2296. Caridad Martín-López
  2297. José-Ángel Martín-Oterino
  2298. Laura Martin-Pedraza
  2299. María Martín-Vicente
  2300. Amalia Martinez
  2301. Ricardo Martínez
  2302. Juan José Martínez
  2303. Silvia Martínez
  2304. Eleno Martínez-Aquino
  2305. Óscar Martínez-González
  2306. Iciar Martinez-Lopez
  2307. Oscar Martinez-Nieto
  2308. Pedro Martinez-Paz
  2309. Angel Martinez-Perez
  2310. Andrea Martínez-Ramas
  2311. Michel F. Martinez-Resendez
  2312. Violeta Martínez Robles
  2313. Laura Marzal
  2314. Juliana F. Mazzeu
  2315. Jeane F. P. Medeiros
  2316. Kelliane A. Medeiros
  2317. Francisco J. Medrano
  2318. Xose M. Meijome
  2319. Natalia Mejuto-Montero
  2320. Ana Méndez-Echevarria
  2321. Humberto Mendoza Charris
  2322. Eleuterio Merayo Macías
  2323. Fátima Mercadillo
  2324. Arieh R. Mercado-Sesma
  2325. Pablo Minguez
  2326. Antonio J. J. Molina
  2327. Elena Molina-Roldán
  2328. Juan José Montoya
  2329. Vitor M. S. Moraes
  2330. Patricia Moreira-Escriche
  2331. Xenia Morelos-Arnedo
  2332. Antonio Moreno-Docón
  2333. Junior Moreno-Escalante
  2334. Victor Moreno Cuerda
  2335. Alberto Moreno Fernández
  2336. Rubén Morilla
  2337. Patricia Muñoz García
  2338. Pablo Neira
  2339. Julian Nevado
  2340. Israel Nieto-Gañán
  2341. Joana F. R. Nunes
  2342. Rocio Nuñez-Torres
  2343. Antònia Obrador-Hevia
  2344. J. Gonzalo Ocejo-Vinyals
  2345. Virginia Olivar
  2346. Silviene F. Oliveira
  2347. Lorena Ondo
  2348. Alberto Orfao
  2349. Luis Ortega
  2350. Eva Ortega-Paino
  2351. Fernando Ortiz-Flores
  2352. Rocio Ortiz-Lopez
  2353. José A. Oteo
  2354. Harry Pachajoa
  2355. Manuel Pacheco
  2356. Fredy Javier Pacheco-Miranda
  2357. Irene Padilla Conejo
  2358. Sonia Panadero-Fajardo
  2359. Mara Parellada
  2360. Roberto Pariente-Rodríguez
  2361. Estela Paz-Artal
  2362. Germán Peces-Barba
  2363. Miguel S. Pedromingo Kus
  2364. Celia Perales
  2365. Patricia Perez
  2366. César Pérez
  2367. Gustavo Perez-de-Nanclares
  2368. Felipe Pérez-García
  2369. Patricia Pérez-Matute
  2370. Alexandra Pérez-Serra
  2371. M. Elena Pérez-Tomás
  2372. Teresa Perucho
  2373. Lisbeth A. Pichardo
  2374. Susana M. T. Pinho
  2375. Mel·lina Pinsach-Abuin
  2376. Luz Adriana Pinzón
  2377. Guillermo Pita
  2378. Francesc Pla-Junca
  2379. Laura Planas-Serra
  2380. Ericka N. Pompa-Mera
  2381. Gloria L. Porras-Hurtado
  2382. Aurora Pujol
  2383. María Eugenia Quevedo Chávez
  2384. Maria Angeles Quijada
  2385. Inés Quintela
  2386. Diana Ramirez-Montaño
  2387. Soraya Ramiro León
  2388. Pedro Rascado Sedes
  2389. Delia Recalde
  2390. Emma Recio-Fernández
  2391. Salvador Resino
  2392. Adriana P. Ribeiro
  2393. Carlos S. Rivadeneira-Chamorro
  2394. Diana Roa-Agudelo
  2395. Montserrat Robelo Pardo
  2396. Marilyn Johanna Rodriguez
  2397. Fernando Rodriguez-Artalejo
  2398. Marena Rodríguez-Ferrer
  2399. Carlos Rodriguez-Gallego
  2400. José A. Rodriguez-Garcia
  2401. María A. Rodriguez-Hernandez
  2402. Antonio Rodriguez-Nicolas
  2403. Agustí Rodriguez-Palmero
  2404. Emilio Rodríguez-Ruiz
  2405. Paula A. Rodriguez-Urrego
  2406. Belén Rodríguez Maya
  2407. German Ezequiel Rodriguez Novoa
  2408. Federico Rojo
  2409. Andrea Romero-Coronado
  2410. Filomeno Rondón García
  2411. Lidia S. Rosa
  2412. Antonio Rosales-Castillo
  2413. Cladelis Rubio
  2414. María Rubio Olivera
  2415. Montserrat Ruiz
  2416. Francisco Ruiz-Cabello
  2417. Eva Ruiz-Casares
  2418. Juan J. Ruiz-Cubillan
  2419. Javier Ruiz-Hornillos
  2420. Pablo Ryan
  2421. Hector D. Salamanca
  2422. Lorena Salazar-García
  2423. Giorgina Gabriela Salgueiro Origlia
  2424. Pedro-Luis Sánchez
  2425. Clara Sánchez-Pablo
  2426. Olga Sánchez-Pernaute
  2427. Antonio J. Sánchez López
  2428. María Concepción Sánchez Prados
  2429. Javier Sánchez Real
  2430. Jorge Sánchez Redondo
  2431. Cristina Sancho-Sainz
  2432. Anna Sangil
  2433. Arnoldo Santos
  2434. Ney P. C. Santos
  2435. Agatha Schlüter
  2436. Sonia Segovia
  2437. Alex Serra-Llovich
  2438. Fernando Sevil Puras
  2439. Marta Sevilla Porras
  2440. Miguel A. Sicolo
  2441. Vivian N. Silbiger
  2442. Nayara S. Silva
  2443. Fabiola T. C. Silva
  2444. Cristina Silván Fuentes
  2445. Jordi Solé-Violán
  2446. José Manuel Soria
  2447. Jose V. Sorlí
  2448. Renata R. Sousa
  2449. Juan Carlos Souto
  2450. Karla S. C. Souza
  2451. Vanessa S. Souza
  2452. John J. Sprockel
  2453. José Javier Suárez-Rama
  2454. David A. Suarez-Zamora
  2455. Xiana Taboada-Fraga
  2456. Eduardo Tamayo
  2457. Alvaro Tamayo-Velasco
  2458. Juan Carlos Taracido-Fernandez
  2459. Nathali A. C. Tavares
  2460. Carlos Tellería
  2461. Jair Antonio Tenorio Castaño
  2462. Alejandro Teper
  2463. Juan Torres-Macho
  2464. Lilian Torres-Tobar
  2465. Ronald P. Torres Gutiérrez
  2466. Jesús Troya
  2467. Miguel Urioste
  2468. Juan Valencia-Ramos
  2469. Agustín Valido
  2470. Juan Pablo Vargas Gallo
  2471. Belén Varón
  2472. Romero H. T. Vasconcelos
  2473. Tomas Vega
  2474. Santiago Velasco-Quirce
  2475. Valentina Vélez-Santamaría
  2476. Virginia Víctor
  2477. Julia Vidán Estévez
  2478. Miriam Vieitez-Santiago
  2479. Carlos Vilches
  2480. Lavinia Villalobos
  2481. Felipe Villar
  2482. Judit Villar-Garcia
  2483. Cristina Villaverde
  2484. Pablo Villoslada-Blanco
  2485. Ana Virseda-Berdices
  2486. Zuleima Yáñez
  2487. Antonio Zapatero-Gaviria
  2488. Ruth Zarate
  2489. Sandra Zazo
  2490. Miguel López de Heredia
  2491. Ingrid Mendes
  2492. Rocío Moreno
  2493. Esther Sande
  2494. Pablo Lapunzina
  2495. Angel Carracedo
  2496. Beatrice Alex
  2497. Petros Andrikopoulos
  2498. Benjamin Bach
  2499. Wendy S. Barclay
  2500. Debby Bogaert
  2501. Meera Chand
  2502. Kanta Chechi
  2503. Graham S. Cooke
  2504. Ana da Silva Filipe
  2505. Thushan de Silva
  2506. Annemarie B. Docherty
  2507. Gonçalo dos Santos Correia
  2508. Marc-Emmanuel Dumas
  2509. Jake Dunning
  2510. Tom Fletcher
  2511. Christopher A. Green
  2512. William Greenhalf
  2513. Julian Griffin
  2514. Rishi K. Gupta
  2515. Ewen M. Harrison
  2516. Antonia Y. W. Ho
  2517. Karl Holden
  2518. Peter W. Horby
  2519. Samreen Ijaz
  2520. Say Khoo
  2521. Paul Klenerman
  2522. Andrew Law
  2523. Matthew Lewis
  2524. Sonia Liggi
  2525. Wei Shen Lim
  2526. Lynn Maslen
  2527. Alexander J. Mentzer
  2528. Laura Merson
  2529. Alison M. Meynert
  2530. Shona C. Moore
  2531. Mahdad Noursadeghi
  2532. Michael Olanipekun
  2533. Anthonia Osagie
  2534. Massimo Palmarini
  2535. Carlo Palmieri
  2536. William A. Paxton
  2537. Georgios Pollakis
  2538. Nicholas Price
  2539. Andrew Rambaut
  2540. David L. Robertson
  2541. Clark D. Russell
  2542. Vanessa Sancho-Shimizu
  2543. Caroline Sands
  2544. Janet T. Scott
  2545. Louise Sigfrid
  2546. Tom Solomon
  2547. Shiranee Sriskandan
  2548. David Stuart
  2549. Olivia V. Swann
  2550. Zoltan Takats
  2551. Panteleimon Takis
  2552. Richard S. Tedder
  2553. A. A. Roger Thompson
  2554. Emma C. Thomson
  2555. Ryan S. Thwaites
  2556. Lance C. W. Turtle
  2557. Maria Zambon
  2558. Gail Carson
  2559. Thomas M. Drake
  2560. Cameron J. Fairfield
  2561. Stephen R. Knight
  2562. Kenneth A. Mclean
  2563. Derek Murphy
  2564. Lisa Norman
  2565. Riinu Pius
  2566. Catherine A. Shaw
  2567. Marie Connor
  2568. Jo Dalton
  2569. Carrol Gamble
  2570. Michelle Girvan
  2571. Sophie Halpin
  2572. Janet Harrison
  2573. Clare Jackson
  2574. Laura Marsh
  2575. Stephanie Roberts
  2576. Egle Saviciute
  2577. Susan Knight
  2578. Eva Lahnsteiner
  2579. Gary Leeming
  2580. Lucy Norris
  2581. James Scott-Brown
  2582. Sarah Tait
  2583. Murray Wham
  2584. James Lee
  2585. Daniel Plotkin
  2586. Seán Keating
  2587. Cara Donegan
  2588. Rebecca G. Spencer
  2589. Chloe Donohue
  2590. Hayley Hardwick
  2591. Janie F. Shelton
  2592. Anjali J. Shastri
  2593. Chelsea Ye
  2594. Catherine H. Weldon
  2595. Teresa Filshtein-Sonmez
  2596. Daniella co*ker
  2597. Antony Symons
  2598. Jorge Esparza-Gordillo
  2599. Stella Aslibekyan
  2600. Adam Auton
  2601. Jian Yang
  2602. Chris P. Ponting
  2603. James F. Wilson
  2604. Veronique Vitart
  2605. Malak Abedalthagafi
  2606. Andre D. Luchessi
  2607. Esteban J. Parra
  2608. Raquel Cruz
  2609. Angel Carracedo
  2610. Angie Fawkes
  2611. Lee Murphy
  2612. Kathy Rowan
  2613. Alexandre C. Pereira
  2614. Andy Law
  2615. Benjamin Fairfax
  2616. Sara Clohisey Hendry
  2617. J. Kenneth Baillie
  2618. GenOMICC Investigators
  2619. Co-Investigators
  2620. Management, Laboratory and Data Team
  2621. Guys and St Thomas’ Hospital, London, UK
  2622. James Cook University Hospital, Middlesbrough, UK
  2623. Barts Health NHS Trust, London, UK
  2624. Royal Stoke University Hospital, Staffordshire, UK
  2625. North Middlesex University Hospital NHS trust, London, UK
  2626. King’s College Hospital, London, UK
  2627. Charing Cross Hospital, St Mary’s Hospital and Hammersmith Hospital, London, UK
  2628. The Royal Liverpool University Hospital, Liverpool, UK
  2629. John Radcliffe Hospital, Oxford, UK
  2630. Addenbrooke’s Hospital, Cambridge, UK
  2631. Nottingham University Hospital, Nottingham, UK
  2632. St George’s Hospital, London, UK
  2633. BHRUT (Barking Havering)—Queens Hospital and King George Hospital, Essex, UK
  2634. Royal Infirmary of Edinburgh, Edinburgh, UK
  2635. Kingston Hospital, Surrey, UK
  2636. Queen Alexandra Hospital, Portsmouth, UK
  2637. Royal Gwent Hospital, Newport, UK
  2638. Royal Blackburn Teaching Hospital, Blackburn, UK
  2639. Stepping Hill Hospital, Stockport, UK
  2640. Northumbria Healthcare NHS Foundation Trust, North Shields, UK
  2641. Countess of Chester Hospital, Chester, UK
  2642. Pinderfields General Hospital, Wakefield, UK
  2643. Ninewells Hospital, Dundee, UK
  2644. Croydon University Hospital, Croydon, UK
  2645. Morriston Hospital, Swansea, UK
  2646. Queen Elizabeth University Hospital, Glasgow, UK
  2647. Broomfield Hospital, Chelmsford, UK
  2648. Heartlands Hospital, Birmingham, UK
  2649. Royal Sussex County Hospital, Brighton, UK
  2650. York Hospital, York, UK
  2651. Queen Elizabeth Hospital, Birmingham, UK
  2652. Royal Glamorgan Hospital, Pontyclun, UK
  2653. Barnet Hospital, London, UK
  2654. Wythenshawe Hospital, Manchester, UK
  2655. Medway Maritime Hospital, Gillingham, UK
  2656. Royal Berkshire NHS Foundation Trust, Berkshire, UK
  2657. Whiston Hospital, Prescot, UK
  2658. The Royal Oldham Hospital, Manchester, UK
  2659. Chesterfield Royal Hospital Foundation Trust, Chesterfield, UK
  2660. Aberdeen Royal Infirmary, Aberdeen, UK
  2661. Royal Devon and Exeter Hospital, Exeter, UK
  2662. Glasgow Royal Infirmary, Glasgow, UK
  2663. Blackpool Victoria Hospital, Blackpool, UK
  2664. Southampton General Hospital, Southampton, UK
  2665. Ashford and St Peter’s Hospital, Surrey, UK
  2666. Derriford Hospital, Plymouth, UK
  2667. East Surrey Hospital, Redhill, UK
  2668. Poole Hospital, Poole, UK
  2669. Royal Alexandra Hospital, Paisley, UK
  2670. St James’s University Hospital and Leeds General Infirmary, Leeds, UK
  2671. Bedford Hospital, Bedford, UK
  2672. Southport and Formby District General Hospital, Ormskirk, UK
  2673. The Tunbridge Wells Hospital and Maidstone Hospital, Kent, UK
  2674. Queen Elizabeth Hospital, Woolwich, London, UK
  2675. North Manchester General Hospital, Manchester, UK
  2676. Royal Victoria Infirmary, Newcastle Upon Tyne, UK
  2677. Hull Royal Infirmary, Hull, UK
  2678. Manchester Royal Infirmary, Manchester, UK
  2679. Royal Derby Hospital, Derby, UK
  2680. Aintree University Hospital, Liverpool, UK
  2681. Fairfield General Hospital, Bury, UK
  2682. Norfolk and Norwich University hospital (NNUH), Norwich, UK
  2683. Milton Keynes University Hospital, Milton Keynes, UK
  2684. Good Hope Hospital, Birmingham, UK
  2685. Queen Elizabeth Hospital Gateshead, Gateshead, UK
  2686. Royal Bolton Hospital, Bolton, UK
  2687. Tameside General Hospital, Ashton Under Lyne, UK
  2688. Salford Royal Hospital, Manchester, UK
  2689. Great Ormond St Hospital and UCL Great Ormond St Institute of Child Health NIHR Biomedical Research Centre, London, UK
  2690. Southmead Hospital, Bristol, UK
  2691. William Harvey Hospital, Ashford, UK
  2692. Arrowe Park Hospital, Wirral, UK
  2693. Royal Hampshire County Hospital, Hampshire, UK
  2694. Bradford Royal Infirmary, Bradford, UK
  2695. Glan Clwyd Hospital, Bodelwyddan, UK
  2696. Royal Bournemouth Hospital, Bournemouth, UK
  2697. Bristol Royal Infirmary, Bristol, UK
  2698. University Hospital North Durham, Darlington, UK and Darlington Memorial Hospital, Darlington, UK
  2699. Basildon Hospital, Basildon, UK
  2700. University College Hospital, London, UK
  2701. Whittington Hospital, London, UK
  2702. Western General Hospital, Edinburgh, UK
  2703. Ipswich Hospital, Ipswich, UK
  2704. Hereford County Hospital, Hereford, UK
  2705. Sunderland Royal Hospital, Sunderland, UK
  2706. Queens Hospital Burton, Burton-On-Trent, UK
  2707. Musgrove Park Hospital, Taunton, UK
  2708. The Royal Papworth Hospital, Cambridge, UK
  2709. University Hospital Lewisham, London, UK
  2710. The Princess Alexandra Hospital, Harlow, UK
  2711. University Hospital of Wales, Cardiff, UK
  2712. West Middlesex Hospital, Isleworth, UK
  2713. Royal Albert Edward Infirmary, Wigan, UK
  2714. Stoke Mandeville Hospital, Buckinghamshire, UK
  2715. Royal Lancaster Infirmary, Lancaster, UK
  2716. Basingstoke and North Hampshire Hospital, Basingstoke, UK
  2717. Worthing Hospital, Worthing, UK and St Richard’s Hospital, Chichester, UK
  2718. The Alexandra Hospital, Redditch and Worcester Royal Hospital, Worcester, UK
  2719. Royal Cornwall Hospital, Truro, UK
  2720. Watford General Hospital, Watford, UK
  2721. Macclesfield District General Hospital, Macclesfield, UK
  2722. Royal Surrey County Hospital, Guildford, UK
  2723. Rotherham General Hospital, Rotherham, UK
  2724. Craigavon Area Hospital, County Armagh, Northern Ireland
  2725. King’s Mill Hospital, Nottingham, UK
  2726. Dumfries and Galloway Royal Infirmary, Dumfries, UK
  2727. Prince Charles Hospital, Merthyr Tydfil, UK
  2728. Ysbyty Gwynedd, Bangor, UK
  2729. Royal Preston Hospital, Preston, UK
  2730. The Great Western Hospital, Swindon, UK
  2731. Lincoln County Hospital, Lincoln, UK
  2732. University Hospital of North Tees, Stockton on Tees, UK
  2733. Glangwili General Hospital, Camarthen, UK
  2734. Southend University Hospital, Westcliff-on-Sea, UK
  2735. Lister Hospital, Stevenage, UK
  2736. Diana Princess of Wales Hospital, Grimsby, UK
  2737. West Suffolk Hospital, Bury St Edmunds, UK
  2738. Victoria Hospital, Kirkcaldy, UK
  2739. Calderdale Royal Hospital, Halifax, UK and Huddersfield Royal Infirmary, Huddersfield, UK
  2740. Dorset County Hospital, Dorchester, UK
  2741. Russell’s Hall Hospital, Dudley, UK
  2742. Royal United Hospital, Bath, UK
  2743. St Mary’s Hospital, Newport, UK
  2744. George Eliot Hospital NHS Trust, Nuneaton, UK
  2745. Yeovil Hospital, Yeovil, UK
  2746. Forth Valley Royal Hospital, Falkirk, UK
  2747. Frimley Park Hospital, Surrey, UK
  2748. Chelsea & Westminster NHS Foundation Trust, London, UK
  2749. Queen Elizabeth the Queen Mother Hospital, Margate, UK
  2750. Royal Brompton Hospital, London, UK
  2751. Darent Valley Hospital, Dartford, UK
  2752. University Hospital Crosshouse, Kilmarnock, UK
  2753. University Hospital Wishaw, Wishaw, UK
  2754. University College Dublin, St Vincent’s University Hospital, Dublin, Ireland
  2755. The Queen Elizabeth Hospital, King’s Lynn, UK
  2756. Walsall Manor Hospital, Walsall, UK
  2757. Princess Royal Hospital, Brighton, UK
  2758. Barnsley Hospital, Barnsley, UK
  2759. Warrington General Hospital, Warrington, UK
  2760. Royal Victoria Hospital, Belfast, NI
  2761. Royal Hallamshire Hospital and Northern General Hospital, Sheffield, UK
  2762. Harefield Hospital, London, UK
  2763. Cumberland Infirmary, Carlisle, UK
  2764. Eastbourne District General Hospital, East Sussex, UK and Conquest Hospital, East Sussex, UK
  2765. Salisbury District Hospital, Salisbury, UK
  2766. Airedale General Hospital, Keighley, UK
  2767. Leicester Royal Infirmary, Leicester, UK
  2768. Peterborough City Hospital, Peterborough, UK and Hinchingbrooke Hospital, Huntingdon, UK
  2769. Colchester General Hospital, Colchester, UK
  2770. Princess Royal Hospital, Telford and Royal Shrewsbury Hospital, Shrewsbury, UK
  2771. University Hospital Monklands, Airdrie, UK
  2772. Wrexham Maelor Hospital, Wrexham, Wales
  2773. Royal Hospital for Children, Glasgow, UK
  2774. New Cross Hospital, Wolverhampton, UK
  2775. University Hospital Hairmyres, East Kilbride, UK
  2776. Warwick Hospital, Warwick, UK
  2777. Sandwell General Hospital and City Hospital, Birmingham, UK
  2778. Royal Manchester Children’s Hospital, Manchester, UK
  2779. Gloucestershire Royal Hospital, Gloucester, UK
  2780. University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK
  2781. Torbay Hospital, Torquay, UK
  2782. Pilgrim Hospital, Lincoln, UK
  2783. Prince Philip Hospital, Lianelli, UK
  2784. Princess of Wales Hospital, Llantrisant, UK
  2785. Northampton General Hospital NHS Trust, Northampton, UK
  2786. The Christie NHS Foundation Trust, Manchester, UK
  2787. James Paget University Hospital NHS Trust, Great Yarmouth, UK
  2788. Birmingham Children’s Hospital, Birmingham, UK
  2789. Withybush General Hospital, Pembrokeshire, Wales
  2790. Northwick Park Hospital, London, UK
  2791. North Devon District Hospital, Barnstaple, UK
  2792. Sc*nthorpe General Hospital, Sc*nthorpe, UK
  2793. Royal Free Hospital, London, UK
  2794. Raigmore Hospital, Inverness, UK
  2795. West Cumberland Hospital, Whitehaven, UK
  2796. Furness General Hospital, Barrow-in-Furness, UK
  2797. Liverpool Heart and Chest Hospital, Liverpool, UK
  2798. Scarborough General Hospital, Scarborough, UK
  2799. Bronglais General Hospital, Aberystwyth, UK
  2800. Alder Hey Children’s Hospital, Liverpool, UK
  2801. Borders General Hospital, Melrose, UK
  2802. Leighton Hospital, Cheshire, UK
  2803. Kent & Canterbury Hospital, Canterbury, UK
  2804. Harrogate and District NHS Foundation Trust, Harrogate, UK
  2805. The Royal Marsden Hospital, London, UK
  2806. Ealing Hospital, Southall, UK
  2807. St John’s Hospital Livingston, Livingston, UK
  2808. Wexham Park Hospital, Slough, UK
  2809. Sheffield Children’s Hospital, Sheffield, UK
  2810. Homerton University Hospital Foundation NHS Trust, London UK
  2811. National Hospital for Neurology and Neurosurgery, London, UK
  2812. The Royal Alexandra Children’s Hospital, Brighton, UK
  2813. Golden Jubilee National Hospital, Clydebank, UK
  2814. SCOURGE Consortium
  2815. ISARICC Investigators
  2816. Co-Investigators
  2817. Data Analysis Team
  2818. Data Architecture Team
  2819. Data Analysis and Management Team
  2820. Project Administration Team
  2821. Project Management Team
  2822. The 23andMe COVID-19 Team

Анотація

AbstractCritical illness in COVID-19 is an extreme and clinically hom*ogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Список літератури

  1. Pairo-Castineira, E. et al. Genetic mechanisms of critical illness in COVID-19. Nature 591, 92–98 (2021).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (3) https://doi.org/10.1038/s41586-020-03065-y
  2. Kousathanas, A. et al. Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature 607, 97–103 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (4) https://doi.org/10.1038/s41586-022-04576-6
  3. Abani, O. et al. Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. Lancet 400, 359–368 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (5) https://doi.org/10.1016/S0140-6736(22)01109-6
  4. Pathak, G. A. et al. A first update on mapping the human genetic architecture of COVID-19. Nature 608, E1–E10 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (6) https://doi.org/10.1038/s41586-022-04826-7
  5. Zhu, Z. et al. Causal associations between risk factors and common diseases inferred from GWAS summary data. Nat. Commun. 9, 224 (2018).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (7) https://doi.org/10.1038/s41467-017-02317-2
  6. Chinnery, P. F. et al. Choosing drugs for UK COVID-19 treatment trials. Nat. Rev. Drug Discov. 21, 81–82 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (8) https://doi.org/10.1038/d41573-021-00203-7
  7. Peng, T., Qi, B., He, J., Ke, H. & Shi, J. Advances in the development of phosphodiesterase-4 inhibitors. J. Med. Chem. 63, 10594–10617 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (9) https://doi.org/10.1021/acs.jmedchem.9b02170
  8. Sanz, M.-J. et al. Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability. Br. J. Pharmacol. 152, 481–92 (2007).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (10) https://doi.org/10.1038/sj.bjp.0707428
  9. Forrest, A. R. R. et al. A promoter-level mammalian expression atlas. Nature 507, 462–470 (2014).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (11) https://doi.org/10.1038/nature13182
  10. Brewitz, A. et al. CD8. Immunity 46, 205–219 (2017).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (12) https://doi.org/10.1016/j.immuni.2017.01.003
  11. Wilson, C. L., Hung, C. F. & Schnapp, L. M. Endotoxin-induced acute lung injury in mice with postnatal deletion of nephronectin. PLoS ONE 17, e0268398 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (13) https://doi.org/10.1371/journal.pone.0268398
  12. David, A. et al. A common TMPRSS2 variant has a protective effect against severe COVID-19. Curr. Res. Transl. Med. 70, 103333 (2022).
  13. Meng, B. et al. Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature https://doi.org/10.1038/s41586-022-04474-x (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (14) https://doi.org/10.1038/s41586-022-04474-x
  14. Li, B. et al. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat. Commun. 11, 164 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (15) https://doi.org/10.1038/s41467-019-13965-x
  15. Parkinson, N. et al. Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19. Sci. Rep. 10, 22303 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (16) https://doi.org/10.1038/s41598-020-79033-3
  16. Hoffmann, H.-H. et al. Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors. Preprint at bioRxiv https://doi.org/10.1101/2020.09.11.291716 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (17) https://doi.org/10.1101/2020.09.11.291716
  17. Russell, C. D., Lone, N. I. & Baillie, J. K. Comorbidities, multimorbidity and COVID-19. Nat. Med. 29, 334–343 (2023).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (18) https://doi.org/10.1038/s41591-022-02156-9
  18. Niemi, M. E. K. et al. Mapping the human genetic architecture of COVID-19. Nature 600, 472–477 (2021).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (19) https://doi.org/10.1038/s41586-021-03767-x
  19. Ellinghaus, D. et al. Genomewide association study of severe COVID-19 with respiratory failure. New Engl. J. Med. 383, 1522–1534 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (20) https://doi.org/10.1056/NEJMoa2020283
  20. Cruz, R. et al. Novel genes and sex differences in COVID-19 severity. Hum. Mol. Genet. 31, 3789–3806 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (21) https://doi.org/10.1093/hmg/ddac132
  21. Degenhardt, F. et al. Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Hum. Mol. Genet. 31, 3945–3966 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (22) https://doi.org/10.1093/hmg/ddac158
  22. Jumper, J. et al. Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589 (2021).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (23) https://doi.org/10.1038/s41586-021-03819-2
  23. Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (24) https://doi.org/10.1093/bioinformatics/btq340
  24. Durinck, S., Spellman, P. T., Birney, E. & Huber, W. Mapping identifiers for the integration of genomic datasets with the r/bioconductor package biomaRt. Nat. Protoc. 4, 1184–1191 (2009).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (25) https://doi.org/10.1038/nprot.2009.97
  25. Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (26) https://doi.org/10.1016/j.ajhg.2010.11.011
  26. Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369–375 (2012).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (27) https://doi.org/10.1038/ng.2213
  27. Wang, G., Sarkar, A., Carbonetto, P. & Stephens, M. A simple new approach to variable selection in regression, with application to genetic fine mapping. J. R. Stat. Soc. B 82, 1273–1300 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (28) https://doi.org/10.1111/rssb.12388
  28. Li, A. et al. mBAT-combo: a more powerful test to detect gene-trait associations from GWAS data. Preprint at bioRxiv https://doi.org/10.1101/2022.06.27.497850 (2022).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (29) https://doi.org/10.1101/2022.06.27.497850
  29. Bernabeu, E. et al. Sex differences in genetic architecture in the UK Biobank. Nature 53, 1283–1289 (2021).
  30. Sun, B. B. et al. Genomic atlas of the human plasma proteome. Nature 558, 73–79 (2018).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (30) https://doi.org/10.1038/s41586-018-0175-2
  31. Võsa, U. et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat. Genet. 53, 1300–1310 (2021).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (31) https://doi.org/10.1038/s41588-021-00913-z
  32. Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481–487 (2016).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (32) https://doi.org/10.1038/ng.3538
  33. The GTEX Consortium. The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science 369, 1318–1330 (2020).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (33) https://doi.org/10.1126/science.aaz1776
  34. Gamazon, E. R. et al. A gene-based association method for mapping traits using reference transcriptome data. Nat. Genet. 47, 1091–1098 (2015).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (34) https://doi.org/10.1038/ng.3367
  35. Barbeira, A. N. et al. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat. Commun. 9, 1825 (2018).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (35) https://doi.org/10.1038/s41467-018-03621-1
  36. Barbeira, A. N. et al. Integrating predicted transcriptome from multiple tissues improves association detection. PLoS Genet. 15, e1007889 (2019).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (36) https://doi.org/10.1371/journal.pgen.1007889
  37. Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245–252 (2016).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (37) https://doi.org/10.1038/ng.3506
  38. Boggs, P. T. & Rogers, J. E. Orthogonal distance regression. Contemp. Math. 112, 183–194 (1990).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (38) https://doi.org/10.1090/conm/112/1087109
  39. Liang, J. et al. Lead identification of novel and selective TYK2 inhibitors. Eur. J. Med. Chem. 67, 175–87 (2013).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (39) https://doi.org/10.1016/j.ejmech.2013.03.070
  40. Li, Z. et al. Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent. J. Immunol. 190, 2335–2344 (2013).
    GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (40) https://doi.org/10.4049/jimmunol.1203118

Публікації, які цитують цю публікацію

Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population

Marta C. Cruz Cisneros, Elizabeth J. Anderson, Brea K. Hampton, Breantié Parotti, Sanjay Sarkar, Sharon Taft-Benz, Timothy A. Bell, Matthew Blanchard, Jacob A. Dillard, Kenneth H. Dinnon, Pablo Hock, Sarah R. Leist, Emily A. Madden, Ginger D. Shaw, Ande West, Ralph S. Baric, Victoria K. Baxter, Fernando Pardo-Manuel de Villena, Mark T. Heise, Martin T. Ferris

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (41) https://doi.org/10.3390/vaccines12010103 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (42)

2024, Vaccines, №1, с.103

Scopus

WoS

Цитувань Crossref:0

Plasma proteomic associates of infection mortality in UK Biobank

Michael Drozd, Fergus Hamilton, Chew W Cheng, Patrick J Lillie, Oliver I Brown, Natalie Chaddock, Sinisa Savic, Khalid Naseem, Mark M Iles, Ann W Morgan, Mark T Kearney, Richard M Cubbon

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (43) https://doi.org/10.1101/2024.01.21.24301569

2024

Цитувань Crossref:0

Priority index for critical Covid-19 identifies clinically actionable targets and drugs

Zhiqiang Zhang, Shan Wang, Lulu Jiang, Jianwen Wei, Chang Lu, Shengli Li, Yizhu Diao, Zhongcheng Fang, Shuo He, Tingting Tan, Yisheng Yang, Kexin Zou, Jiantao Shi, James Lin, Liye Chen, Chaohui Bao, Jian Fei, Hai Fang

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (44) https://doi.org/10.1038/s42003-024-05897-0 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (45)

2024, Communications Biology, №1

Scopus

WoS

Цитувань Crossref:0

Molecular Profile of Variants Potentially Associated with Severe Forms of COVID-19 in Amazonian Indigenous Populations

Rita de Cássia Calderaro Coelho, Carlliane Lima e Lins Pinto Martins, Lucas Favacho Pastana, Juliana Carla Gomes Rodrigues, Kaio Evandro Cardoso Aguiar, Amanda de Nazaré Cohen-Paes, Laura Patrícia Albarello Gellen, Francisco Cezar Aquino de Moraes, Maria Clara Leite Calderaro, Letícia Almeida de Assunção, Natasha Monte, Esdras Edgar Batista Pereira, André Maurício Ribeiro-dos-Santos, Ândrea Ribeiro-do-Santos, Rommel Mario Rodriguez Burbano, Sandro José de Souza, João Farias Guerreiro, Paulo Pimentel de Assumpção, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (46) https://doi.org/10.3390/v16030359 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (47)

2024, Viruses, №3, с.359

Scopus

WoS

Цитувань Crossref:0

Evaluating the effects of circulating inflammatory proteins as drivers and therapeutic targets for severe COVID-19

Ancha Baranova, Jing Luo, Li Fu, Guanqun Yao, Fuquan Zhang

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (48) https://doi.org/10.3389/fimmu.2024.1352583 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (49)

2024, Frontiers in Immunology

Scopus

WoS

Цитувань Crossref:0

Association analysis of genetic variants in critical patients with COVID-19 and validation in a Chinese population

Yi Yin, Yi Zhang, Lelin Sun, Shuqiang Wang, Yong Zeng, Bo Gong, Lulin Huang, Yongquan He, Zhenglin Yang

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (50) https://doi.org/10.1016/j.virs.2024.02.004

2024, Virologica Sinica, №2, с.347-350

Scopus

WoS

Цитувань Crossref:0

Landscape of infiltrated immune cell characterization in COVID-19

Wei Zheng, Yuan Zhang, Guichuan Lai, Biao Xie

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (51) https://doi.org/10.1016/j.heliyon.2024.e28174 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (52)

2024, Heliyon, №6, с.e28174

Scopus

WoS

Цитувань Crossref:0

Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans

Alexandra Schäfer, Lisa E. Gralinski, Sarah R. Leist, Brea K. Hampton, Michael A. Mooney, Kara L. Jensen, Rachel L. Graham, Sudhakar Agnihothram, Sophia Jeng, Steven Chamberlin, Timothy A. Bell, D. Trevor Scobey, Colton L. Linnertz, Laura A. VanBlargan, Larissa B. Thackray, Pablo Hock, Darla R. Miller, Ginger D. Shaw, Michael S. Diamond, Fernando Pardo Manuel de Villena, Shannon K. McWeeney, Mark T. Heise, Vineet D. Menachery, Martin T. Ferris, Ralph S. Baric

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (53) https://doi.org/10.1016/j.virusres.2024.199357

2024, Virus Research, с.199357

Scopus

WoS

Цитувань Crossref:1

Epigenetic liquid biopsies reveal elevated vascular endothelial cell turnover and erythropoiesis in asymptomatic COVID-19 patients

Roni Ben-Ami, Netanel Loyfer, Eden Cohen, Gavriel Fialkoff, Israa Sharkia, Naama Bogot, Danit Kochan, George Kalak, Amir Jarjoui, Chen Chen-Shuali, Hava Azulai, Hezi Barhoum, Nissim Arish, Moshe M Greenberger, David Vellema, Ramzi Kurd, Eli Ben Chetrit, Davina Bohm, Talya Wolak, Ahmad Quteineh, Gordon Cann, Benjamin Glaser, Nir Friedman, Tommy Kaplan, Ruth Shemer, Ariel Rokach, Yuval Dor

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (54) https://doi.org/10.1101/2023.07.28.550957

2023

Цитувань Crossref:0

Shared genetic architecture of COVID-19 and Alzheimer’s disease

Natalia Matveeva, Ivan Kiselev, Natalia Baulina, Ekaterina Semina, Viktor Kakotkin, Mikhail Agapov, Olga Kulakova, Olga Favorova

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (55) https://doi.org/10.3389/fnagi.2023.1287322 · GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (56)

2023, Frontiers in Aging Neuroscience

Scopus

WoS

Цитувань Crossref:0

Знайти всі цитування публікації

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (2024)
Top Articles
Latest Posts
Article information

Author: Jerrold Considine

Last Updated:

Views: 6286

Rating: 4.8 / 5 (58 voted)

Reviews: 89% of readers found this page helpful

Author information

Name: Jerrold Considine

Birthday: 1993-11-03

Address: Suite 447 3463 Marybelle Circles, New Marlin, AL 20765

Phone: +5816749283868

Job: Sales Executive

Hobby: Air sports, Sand art, Electronics, LARPing, Baseball, Book restoration, Puzzles

Introduction: My name is Jerrold Considine, I am a combative, cheerful, encouraging, happy, enthusiastic, funny, kind person who loves writing and wants to share my knowledge and understanding with you.